Evidence map›Paper›PMID 40060664›Full record

ArticlebioRxiv : the preprint server for biology2025

Structural basis for anomalous cellular trafficking behavior of glaucoma-associated A427T mutant myocilin.

Kamisha R Hill, Hailee F Scelsi, Hannah A Youngblood, Jennifer A Faralli, Tatsuo Itakura, M Elizabeth Fini, Donna M Peters, Raquel L Lieberman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kamisha R HillSchool of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA.
Hailee F ScelsiSchool of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA.
Hannah A YoungbloodSchool of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA.
Jennifer A FaralliDepartment of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI.
Tatsuo ItakuraUSC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA.
M Elizabeth FiniNew England Eye Center, Tufts Medical Center; Department of Ophthalmology, School of Medicine and Tufts Graduate School of Biomedical Sciences, Tufts University, Boston, MA.
Donna M PetersDepartment of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI.
Raquel L LiebermanSchool of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA.ORCID 0000-0001-9345-3735

Funding

Request for Supplement to Promote Diversity in Health Related ResearchR01EY021205 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Raquel L Lieberman · 2011 to 2026
$6.8M
Control of Trabecular Meshwork CytoskeletonR01EY017006 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI PETERS, DONNA M · 2006 to 2024
$6.1M
VIsion Science Training in AtlantaT32EY007092 · NEI · EMORY UNIVERSITY · PI Machelle T. Pardue · 1985 to 2026
$4.6M
An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-IIS10OD030394 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI BATTAILE, KEVIN P · 2021 to 2021
$1.8M
NEI NIH HHS R01 EY017006NEI NIH HHS R01 EY021205NEI NIH HHS T32 EY007092NIH HHS S10 OD030394
6 · The paper itself

Abstract

Familial mutations in myocilin cause vision loss in glaucoma due to misfolding and a toxic gain of function in a senescent cell type in the anterior eye. Here we characterize the cellular behavior and structure of the myocilin (myocilin

Identifiers

PMID40060664
PMCPMC11888440

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.