ArticlebioRxiv : the preprint server for biology2025
Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells.
Robert N Rainey, Sam D Houman, Louise Menendez, Ryan Chang, Litao Tao, Helena Bugacov, Andrew P McMahon, Radha Kalluri, John S Oghalai, Andrew K Groves and 1 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Robert N RaineyDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of University of Southern California, Los Angeles, California, United States.ORCID 0000-0003-2732-493X Sam D HoumanDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of University of Southern California, Los Angeles, California, United States.
Louise MenendezDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of University of Southern California, Los Angeles, California, United States.ORCID 0000-0001-6830-0358 Ryan ChangDornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, United States.
Litao TaoBiomedical Sciences Department, School of Medicine, Creighton University, Omaha, Nebraska, United States.
Helena BugacovDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of University of Southern California, Los Angeles, California, United States.ORCID 0000-0002-9575-3333 Andrew P McMahonDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of University of Southern California, Los Angeles, California, United States.ORCID 0000-0002-3779-1729 Radha KalluriZilkha Neurogenetic Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, United States.ORCID 0000-0002-0360-8965 John S OghalaiUSC Caruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine of University of Southern California, Los Angeles, California, United States.
Andrew K GrovesDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0002-0784-7998 Neil SegilDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of University of Southern California, Los Angeles, California, United States.ORCID 0000-0002-0441-2067 Funding
Enhancing Atoh1 function in hair cell regenerationR01DC014832 · NIDCD · WASHINGTON UNIVERSITY · PI Gabriel Corfas, Andrew K Groves · 2016 to 2026
$6.7MEpigenetic mechanisms underlying the failure of hair cell regeneration in mammalsR01DC015829 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P., OGHALAI, JOHN S · 2018 to 2022
$2.8MTraining in Developmental Biology, Stem Cells and RegenerationT32HD060549 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Gage D Crump · 2011 to 2026
$2.5MNICHD NIH HHS T32 HD060549NIDCD NIH HHS R01 DC014832NIDCD NIH HHS R01 DC015829
6 · The paper itselfAbstract
Mammalian inner ear sensory hair cells are highly sensitive to environmental stress and do not regenerate, making hearing loss progressive and permanent. The paucity and extreme inaccessibility of these cells hinder the development of regenerative and otoprotective strategies, Direct lineage reprogramming to generate large quantities of hair cell-like cells in vitro offers a promising approach to overcome these experimental bottlenecks. Previously, we identified four transcription factors-
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PMID40060658
PMCPMC11888184
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