Evidence map›Paper›PMID 40060612›Full record

ArticlebioRxiv : the preprint server for biology2025

Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia.

Maria Ibrahim, Maria Gomez-Jenkins, Adina Scheinfeld, Zhengqiao Zhao, Eduardo Cararo Lopes, Akshada Sawant, Zhixian Hu, Aditya Dharani, Michael Sun, Sarah Siddiqui and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Maria IbrahimRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.ORCID 0009-0002-9365-1488
Maria Gomez-JenkinsRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.
Adina ScheinfeldLudwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA.
Zhengqiao ZhaoLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.
Eduardo Cararo LopesRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.ORCID 0000-0002-5316-5146
Akshada SawantRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.ORCID 0000-0001-9878-4445
Zhixian HuRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.
Aditya DharaniRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.
Michael SunRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.
Sarah SiddiquiRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.
Emily T MirekDepartment of Nutritional Sciences, Rutgers School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Johan Abram-SalibaLAbCore Immunoglobulin Discovery Platform, Department of Oncology, Ludwig Institute for Cancer Research-Lausanne, University Hospital and University of Lausanne, 1066, Epalinges, Switzerland.
Edmund C LattimeRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.
Xiaoyang SuRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.ORCID 0000-0001-8081-1396
Tobias JanowitzCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Northwell Health Cancer Institute, Northwell Health, New Hyde Park, NY 11042, USA.ORCID 0000-0002-7820-3727
Marcus D GoncalvesDepartments of Medicine and Radiation Oncology, New York University, Grossman School of Medicine, Laura and Isaac Perlmutter Cancer Center, New York, NY 10016, USA.
Steven M DunnLAbCore Immunoglobulin Discovery Platform, Department of Oncology, Ludwig Institute for Cancer Research-Lausanne, University Hospital and University of Lausanne, 1066, Epalinges, Switzerland.
Yuri PritykinLudwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA.
Tracy G AnthonyRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.
Joshua D RabinowitzLudwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ 08544, USA.
Eileen WhiteRutgers Cancer Institute, Rutgers University, New Brunswick, NJ 08903, USA.

Funding

Tumor cell metabolism in actionR01CA163591 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI JOSHUA D RABINOWITZ, Eileen P. White · 2012 to 2026
$7.0M
Impact of mutation burden on cancer growth and the immune landscapeR01CA243547 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI WHITE, EILEEN P. · 2020 to 2024
$3.2M
CANCAN-RUTGERSOT2CA278609 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Eileen P. White · 2022 to 2026
$2.6M
Regulatory genomics of T cells in mouse and humanDP2AI171161 · NIAID · PRINCETON UNIVERSITY · PI Yury Pritykin · 2022 to 2026
$2.4M
Post-doctoral Training Program in Cancer Metabolism and Tumor-host InteractionsT32CA257957 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI KANG, YIBIN, ZONG, WEI-XING · 2021 to 2025
$1.2M
NCI NIH HHS OT2 CA278609NCI NIH HHS R01 CA163591NCI NIH HHS R01 CA243547NCI NIH HHS T32 CA257957NIAID NIH HHS DP2 AI171161
6 · The paper itself

Abstract

Macroautophagy (autophagy hereafter) captures intracellular components and delivers them to lysosomes for degradation and recycling

Identifiers

PMID40060612
PMCPMC11888218

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.