Evidence map›Paper›PMID 40060603›Full record

ArticlebioRxiv : the preprint server for biology2025

Pathway Coessentiality Mapping Reveals Complex II is Required for

Amy E Stewart, Derek K Zachman, Pol Castellano-Escuder, Lois M Kelly, Ben Zolyomi, Michael D I Aiduk, Christopher D Delaney, Ian C Lock, Claudie Bosc, John Bradley and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Derek K Zachman
Pol Castellano-EscuderORCID 0000-0001-6466-877X
Ben Zolyomi
Michael D I AidukORCID 0000-0002-3447-324X
Christopher D DelaneyORCID 0000-0002-4549-6869
Shane T KillarneyORCID 0000-0002-8471-6641
Christopher B NewgardORCID 0000-0002-1293-691X
Navdeep S ChandelORCID 0000-0001-7208-3886
Alexandre PuissantORCID 0000-0002-3997-9282
Matthew D HirscheyORCID 0000-0003-4541-5376

Funding

Pilot & Feasibility ProgramP30DK124723 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Nicholette D. Allred · 2020 to 2026
$11.0M
Unified Program for Therapeutics in Children (UPTiC)T32HD094671 · NICHD · DUKE UNIVERSITY · PI Ian J Davis, Kanecia Obie Zimmerman · 2019 to 2026
$2.9M
Metabolic regulation of oxidative phosphorylation in pediatric AML relapseK38CA282963 · NCI · DUKE UNIVERSITY · PI ZACHMAN, DEREK · 2024 to 2025
$207k
NCI NIH HHS K38 CA282963NICHD NIH HHS T32 HD094671NIDDK NIH HHS P30 DK124723
6 · The paper itself

Abstract

Understanding how cellular pathways interact is crucial for treating complex diseases like cancer, yet our ability to map these connections systematically remains limited. Individual gene-gene interaction studies have provided insights

Identifiers

PMID40060603
PMCPMC11888402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.