Evidence map›Paper›PMID 40060597›Full record

ArticlebioRxiv : the preprint server for biology2025

Epithelial-mesenchymal transition couples with cell cycle arrest at various stages.

Sophia Hu, Yong Lu, Gaohan Yu, Zhiqian Zheng, Weikang Wang, Ke Ni, Amitava Giri, Jingyu Zhang, Yan Zhang, Kazuhide Watanabe and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sophia HuDepartment of Computational and Systems Biology, University of Pittsburgh, USA.ORCID 0000-0002-5950-388X
Yong LuDepartment of Computational and Systems Biology, University of Pittsburgh, USA.
Gaohan YuDepartment of Physics and Astronomy, University of Pittsburgh, USA.
Zhiqian ZhengDepartment of Computational and Systems Biology, University of Pittsburgh, USA.
Weikang WangCAS Key Laboratory for Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China.
Ke NiDepartment of Computational and Systems Biology, University of Pittsburgh, USA.
Amitava GiriDepartment of Computational and Systems Biology, University of Pittsburgh, USA.
Jingyu ZhangDepartment of Computational and Systems Biology, University of Pittsburgh, USA.ORCID 0000-0001-6668-2815
Yan ZhangDepartment of Computational and Systems Biology, University of Pittsburgh, USA.
Kazuhide WatanabeRIKEN Center for Integrative Medical Sciences Yokohama, Japan.ORCID 0000-0002-5331-0593
Guang YaoDepartment of Molecular & Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0003-0167-777X
Jianhua XingDepartment of Computational and Systems Biology, University of Pittsburgh, USA.ORCID 0000-0002-3700-8765

Funding

Role of the Snail1-Twist-p21 axis on cell cycle arrest and renal fibrosis developmentR01DK119232 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XING, JIANHUA · 2019 to 2022
$1.4M
Learn Systems Biology Equations From Snapshot Single Cell Genomic DataR01GM148525 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jianhua Xing · 2023 to 2026
$1.3M
Coupling between cell cycle arrest and epithelial-to-mesenchymal transition in renal fibrosis developmentR56DK119232 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XING, JIANHUA · 2023 to 2023
$100k
NIDDK NIH HHS R01 DK119232NIDDK NIH HHS R56 DK119232NIGMS NIH HHS R01 GM148525
6 · The paper itself

Abstract

Numerous computational approaches have been developed to infer cell state transition trajectories from snapshot single-cell data. Most approaches first require projecting high-dimensional data onto a low-dimensional representation, raising the question of whether the dynamics of the system become distorted. Using epithelial-to-mesenchymal transition (EMT) as a test system, we show that both biology-guided low-dimensional representations and stochastic trajectory simulations in high-dimensional state space, not representations obtained with

Indexed as

cell cycle arrestcouplingdynamical systems theoryEMTsingle-cell RNA-seq

Identifiers

PMID40060597
PMCPMC11888286

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.