Evidence map›Paper›PMID 40060595›Full record

ArticlebioRxiv : the preprint server for biology2025

TNF signaling maintains local restriction of bacterial founder populations in intestinal and systemic sites during oral

Stefan T Peterson, Katherine G Dailey, Karthik Hullahalli, Daniel Sorobetea, Rina Matsuda, Jaydeen Sewell, Winslow Yost, Rosemary O' Neill, Suhas Bobba, Nicolai Apenes and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Stefan T PetersonDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2984-6400
Katherine G DaileyDivision of Infectious Diseases, Brigham & Women's Hospital, Boston, USA.
Karthik HullahalliDivision of Infectious Diseases, Brigham & Women's Hospital, Boston, USA.ORCID 0000-0003-3064-2090
Daniel SorobeteaDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0008-6248-449X
Rina MatsudaDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8279-5788
Jaydeen SewellDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Winslow YostDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0002-8012-972X
Rosemary O' NeillDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0009-7130-2480
Suhas BobbaDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-9276-1469
Nicolai ApenesDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1134-1890
Matthew E ShermanDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.
George I BalazsDivision of Infectious Diseases, Brigham & Women's Hospital, Boston, USA.ORCID 0009-0008-6192-7041
Charles-Antoine AssenmacherDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0073-2730
Arin CoxDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1841-8512
Matthew LanzaDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-5477-3549
Sunny ShinDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Matthew K WaldorDivision of Infectious Diseases, Brigham & Women's Hospital, Boston, USA.ORCID 0000-0003-1843-7000
Igor E BrodskyDepartment of Pathobiology, School of Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7970-872X

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Defining the mechanism and functions of RIPK1-induced cell death in anti-bacterial immune defenseR01AI139102 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2019 to 2023
$2.8M
Dissecting innate immune control of intestinal and systemic Yersinia infectionR01AI191440 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI IGOR E BRODSKY, Sunny Shin · 2025 to 2026
$2.1M
Defining the non-apoptotic role of Caspase-8 activity in anti-bacterial immune defenseR01AI128530 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2017 to 2021
$2.0M
Lymphothrombosis in gut health and diseaseR01DK123528 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E, KAHN, MARK L · 2019 to 2023
$2.0M
Aperio VERSA Digital Slide Scanner, eSlide Manager Database, and Advanced Image Analysis SoftwareS10OD023465 · OD · UNIVERSITY OF PENNSYLVANIA · PI DURHAM, AMY CLEVELAND · 2018 to 2018
$329k
NCI NIH HHS P30 CA016520NIAID NIH HHS R01 AI128530NIAID NIH HHS R01 AI139102NIAID NIH HHS R01 AI191440NIDDK NIH HHS R01 DK123528NIH HHS S10 OD023465
6 · The paper itself

Abstract

Enteroinvasive bacterial pathogens are responsible for an enormous worldwide disease burden that critically affects the young and immunocompromised.

Identifiers

PMID40060595
PMCPMC11888380

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.