Evidence map›Paper›PMID 40060571›Full record

ArticlebioRxiv : the preprint server for biology2025

Phagosome-mediated anti-bacterial immunity is governed by the proton-activated chloride channel in peritoneal macrophages.

Henry Yi Cheng, Jiachen Chu, Nathachit Limjunyawong, Jianan Chen, Yingzhi Ye, Kevin Hong Chen, Nicholas Koylass, Shuying Sun, Xinzhong Dong, Zhaozhu Qiu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Henry Yi ChengDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4412-4235
Jiachen ChuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Nathachit LimjunyawongSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jianan ChenDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Yingzhi YeDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kevin Hong ChenDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Nicholas KoylassDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Shuying SunDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Xinzhong DongSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Zhaozhu QiuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Funding

Molecular Identity and Physiological Function of Novel Chloride ChannelsR35GM124824 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Zhaozhu Qiu · 2017 to 2026
$4.8M
Validation of a new large-pore channel as a novel target for neuropathic painRF1NS134549 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Yun Guan, Zhaozhu Qiu · 2023 to 2026
$3.4M
Cell Swelling-Activated Chloride Channel in Ischemic StrokeR01NS118014 · NINDS · JOHNS HOPKINS UNIVERSITY · PI QIU, ZHAOZHU · 2020 to 2024
$2.6M
NIGMS NIH HHS R35 GM124824NINDS NIH HHS R01 NS118014NINDS NIH HHS RF1 NS134549
6 · The paper itself

Abstract

The success of phagosome degradation relies on the ability of phagocytes to regulate the maturation of phagosomes. However, its underlying molecular mechanisms remain poorly understood. Here, we identify the proton-activated chloride (PAC) channel as a key negative regulator of phagosome maturation. PAC deletion enhanced phagosomal acidification and protease activities, leading to augmented bacterial killing in large peritoneal macrophages (LPMs) upon

Indexed as

gasdermin Dinflammasome activationinterferon responseslarge peritoneal macrophagesphagosomal acidificationPhagosome maturationproton-activated chloride channelSTING-IRF3 signalingTMEM206

Identifiers

PMID40060571
PMCPMC11888413

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.