Evidence map›Paper›PMID 40060545›Full record

ArticlebioRxiv : the preprint server for biology2025

Deciphering Precursor Cell Dynamics in Esophageal Preneoplasia via Genetic Barcoding and Single-Cell Transcriptomics.

Jinho Jang, Kyung-Pil Ko, Jie Zhang, Sohee Jun, Jae-Il Park

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jinho JangDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Kyung-Pil KoDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jie ZhangDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sohee JunDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jae-Il ParkDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-0737-2654

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
PAF-Remodeled DREAM Complex in Cancer and RegenerationR01CA193297 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PARK, JAE-IL · 2015 to 2024
$3.6M
CRACD-controlled cell plasticity and small cell lung cancerR01CA278967 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Jae-Il Park, Kwon-Sik Park · 2024 to 2026
$1.8M
Esophageal Squamous Cell Cancer Initiation and Immune Landscape RemodelingR01CA278971 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Jae-Il Park · 2024 to 2026
$1.7M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Esophageal squamous cell cancer initiation and immune landscape remodelingK99CA286761 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KO, KYUNG PIL · 2024 to 2025
$258k
Esophageal squamous cell cancer initiation and immune landscape remodelingR00CA286761 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Kyung Pil Ko · 2026 to 2026
$249k
Modeling Esophageal Squamous Cell Cancer InitiationR03CA256207 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PARK, JAE-IL · 2021 to 2022
$162k
Calcium metabolism and lung cancer preneoplasiaR03CA279867 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PARK, JAE-IL · 2024 to 2025
$162k
NCI NIH HHS K99 CA286761NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA125123NCI NIH HHS R00 CA286761NCI NIH HHS R01 CA193297NCI NIH HHS R01 CA278967NCI NIH HHS R01 CA278971NCI NIH HHS R03 CA256207NCI NIH HHS R03 CA279867NCRR NIH HHS S10 RR024574
6 · The paper itself

Abstract

Although histologically normal, esophageal preneoplastic cells harbor early genetic alterations and likely exhibit lineage plasticity. However, their origins and trajectories remain unclear. To address this, we combined genetic barcoding with single-cell RNA sequencing to trace the lineage of esophageal preneoplastic cells. We identified a distinct progenitor-like cell population with high plasticity. Through a newly developed scoring system, these high-plasticity cells are mapped, revealing their contributions to proliferative and basal cell populations. This approach uncovers molecular markers, including

Indexed as

cell lineage tracingEsophageal canceresophageal squamous cell cancergenetic barcodingprecursor cellspreneoplasiasingle-cell transcriptomics

Identifiers

PMID40060545
PMCPMC11888434

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.