Evidence map›Paper›PMID 40060533›Full record

ArticlebioRxiv : the preprint server for biology2025

Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system.

David M Brinkley, Savannah K Bertolli, Larry A Gallagher, Yongjun Tan, Minola Motha de Silva, Ainsley Brockman, Dapeng Zhang, S Brook Peterson, Joseph D Mougous

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

David M BrinkleyDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6472-9330
Savannah K BertolliDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Larry A GallagherDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1517-4236
Yongjun TanDepartment of Biology, Saint Louis University, St. Louis, MO, USA.
Minola Motha de SilvaDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Ainsley BrockmanDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Dapeng ZhangDepartment of Biology, Saint Louis University, St. Louis, MO, USA.
S Brook PetersonDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Joseph D MougousDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5417-4861

Funding

Type VI secretion effectors and interbacterial competition in vivoR01AI080609 · NIAID · YALE UNIVERSITY · PI MOUGOUS, JOSEPH DAVID · 2009 to 2025
$6.7M
Training in Cellular & Molecular BiologyT32GM136534 · NIGMS · UNIVERSITY OF WASHINGTON · PI Andrew Atwell Oberst, LARRY S ZWEIFEL · 2021 to 2026
$5.8M
NIAID NIH HHS R01 AI080609NIGMS NIH HHS T32 GM136534
6 · The paper itself

Abstract

Bacterial cells live under the constant existential threats imposed by other bacteria and viruses. Their mechanisms for contending with these threats are well documented; however, the regulation of these diverse defense elements remains poorly understood. Here we show that bacteria can mount a genome-wide, coordinated, and highly effective immune response against bacterial and viral threats using a single regulatory pathway. Bioinformatic analyses revealed that

Identifiers

PMID40060533
PMCPMC11888443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.