Evidence map›Paper›PMID 40060510›Full record

ArticlebioRxiv : the preprint server for biology2025

Loss of Sarm1 Mitigates Axonal Degeneration and Promotes Neuronal Repair After Ischemic Stroke.

Jack T Wang, Brian Toh, Jennifer An, Yutaro Komuro, Marlesa I Godoy, Jennifer Putman, S Thomas Carmichael, Robert Damoiseaux, Jason D Hinman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jack T WangDepartment of Neurology, Stanford University School of Medicine, Palo Alto, CA 94305.
Brian TohDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095.
Jennifer AnDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095.
Yutaro KomuroDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095.ORCID 0000-0003-3256-9755
Marlesa I GodoyDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095.ORCID 0000-0002-7012-1612
Jennifer PutmanDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-5595-9193
S Thomas CarmichaelDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095.ORCID 0000-0002-1169-9203
Robert DamoiseauxDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095.ORCID 0000-0002-7611-7534
Jason D HinmanDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095.ORCID 0000-0002-0872-5044

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARLEY IAN KORNBLUM · 2020 to 2026
$9.6M
Translational Neuroscience Training GrantR25NS065723 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARMICHAEL, STANLEY THOMAS · 2009 to 2023
$2.8M
Molecular Mechanisms of Axonal Degeneration After White Matter StrokeK08NS083740 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HINMAN, JASON D · 2013 to 2017
$831k
NICHD NIH HHS P50 HD103557NINDS NIH HHS K08 NS083740NINDS NIH HHS R25 NS065723
6 · The paper itself

Abstract

Axonal degeneration is a core feature of ischemic brain injury that limits functional recovery (1). The pro-degenerative molecule Sarm1 is required for Wallerian axon degeneration after traumatic and chemotoxic nerve injuries (2), however it is unclear if a similar mechanism mediates axonal degradation after ischemic injury. Here we show that loss of Sarm1 results in profound attenuation of axonal degeneration after focal ischemia to the subcortical white matter. Moreover, absence of Sarm1 significantly promotes the survival of neurons remote from but connected to the infarct after ischemic injuries to the subcortical white matter as well as to the cortex. To further understand the mechanism of

Indexed as

Axonal repairAxon degenerationFunctional GenomicsMajor classification – Biological SciencesMinor Classification – NeuroscienceSarm1Stroke

Identifiers

PMID40060510
PMCPMC11888178

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.