Evidence map›Paper›PMID 40060503›Full record

ArticlebioRxiv : the preprint server for biology2025

Distinct prelimbic cortex ensembles encode response execution and inhibition.

Rajtarun Madangopal, Yuan Zhao, Conor Heins, Jingfeng Zhou, Bo Liang, Giovanni Barbera, Ka Chun Lam, Lauren E Komer, Sophia J Weber, Drake J Thompson and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Rajtarun MadangopalBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Yuan ZhaoMachine Learning Core, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Conor HeinsBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Jingfeng ZhouCellular and Neurocomputational Systems Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Bo LiangBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Giovanni BarberaBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Ka Chun LamMachine Learning Core, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Lauren E KomerBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Sophia J WeberBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Drake J ThompsonBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Yugantar GeraBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Diana Q PhamBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Katherine E SavellBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Brandon L WarrenBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Daniele CaprioliBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Marco VenniroBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Jennifer M BossertBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Leslie A RamseyBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Hank P JedemaBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Geoffrey SchoenbaumCellular and Neurocomputational Systems Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.ORCID 0000-0001-8180-0701
Da-Ting LinBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Yavin ShahamBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.
Francisco PereiraMachine Learning Core, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Bruce T HopeBehavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.

Funding

Machine Learning TeamZICMH002968 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PEREIRA, FRANCISCO · 2018 to 2025
$13.9M
Neurobiology of relapse to heroin &cocaineZ01DA000434 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SHAHAM, YAVIN · 2000 to 2008
$3.3M
Sensitized Neurons that Mediate Sensitized BehaviorZ01DA000467 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HOPE, BRUCE · 2004 to 2008
$1.7M
The role of neuronal ensemble Rac1 activity in cocaine seeking behaviorR01DA059293 · NIDA · UNIVERSITY OF FLORIDA · PI WARREN, BRANDON L · 2024 to 2024
$564k
DEPRESSION PRONE SMOKERS AND CIGARETTE CRAVINGK08DA000467 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCCHARGUE, DENNIS E · 2000 to 2004
$535k
DRUG USE LIABILITY: INVESTIGATING COMPETING MODELSK01DA000434 · NIDA · WASHINGTON UNIVERSITY · PI RIDENOUR, TY A · 2000 to 2004
$535k
Intramural NIH HHS Z01 DA000434Intramural NIH HHS Z01 DA000467Intramural NIH HHS ZIC MH002968NIDA NIH HHS K01 DA000434NIDA NIH HHS K08 DA000467NIDA NIH HHS R01 DA059293
6 · The paper itself

Abstract

Learning when to initiate or withhold actions is essential for survival and requires integration of past experiences with new information to adapt to changing environments. While stable prelimbic cortex (PL) ensembles have been identified during reward learning, it remains unclear how they adapt when contingencies shift. Does the same ensemble adjust its activity to support behavioral suppression upon reward omission, or is a distinct ensemble recruited for this new learning? We used single-cell calcium imaging to longitudinally track PL neurons in rats across operant food reward Training, Extinction and Reinstatement, trained rat-specific decoders to predict trial-wise behavior, and implemented an

Identifiers

PMID40060503
PMCPMC11888377

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.