Evidence map›Paper›PMID 40060495›Full record

ArticlebioRxiv : the preprint server for biology2025

The neuron-intrinsic membrane skeleton is required for motor neuron integrity throughout lifespan.

Carrie Ann Davison, Daniela Garcia, Chengye Feng, Hongyan Hao, Erik M Jorgensen, Marc Hammarlund

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carrie Ann DavisonDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2358-207X
Daniela GarciaDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID 0009-0000-6593-4187
Chengye FengDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7330-4273
Hongyan HaoDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0860-2615
Erik M JorgensenSchool of Biological Sciences, University of Utah, Salt Lake City, UT, USA.
Marc HammarlundDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3068-068X

Funding

WormBase: a core data resource for C. elegans and other nematodesU24HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TIM SCHEDL, PAUL Warren STERNBERG · 2018 to 2026
$18.9M
Discovery and analysis of the C. elegans neuronal gene expression network (CENGEN)R01NS100547 · NINDS · YALE UNIVERSITY · PI MARC HAMMARLUND, Oliver Hobert · 2017 to 2026
$11.2M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANSR01NS034307 · NINDS · UNIVERSITY OF UTAH · PI JORGENSEN, ERIK M · 1995 to 2024
$5.8M
New Mechanisms in Axon RegenerationR01NS094219 · NINDS · YALE UNIVERSITY · PI HAMMARLUND, MARC · 2015 to 2025
$4.0M
Function of the oxidoreductase PYROXD1 in axon regenerationF31NS127495 · NINDS · YALE UNIVERSITY · PI DAVISON, CARRIE ANN · 2022 to 2023
$79k
NHGRI NIH HHS U24 HG002223NIH HHS P40 OD010440NINDS NIH HHS F31 NS127495NINDS NIH HHS R01 NS034307NINDS NIH HHS R01 NS094219NINDS NIH HHS R01 NS100547
6 · The paper itself

Abstract

Axons experience physical stress throughout an organism's lifetime, and disruptions in axonal integrity are hallmarks of both neurodegenerative diseases and traumatic injuries. The spectrin-based membrane periodic skeleton (MPS) is proposed to have a crucial role in maintaining axonal strength, flexibility, and resilience. To investigate the importance of the intrinsic MPS for GABAergic motor neuron integrity in

Identifiers

PMID40060495
PMCPMC11888272

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.