Evidence map›Paper›PMID 40060480›Full record

ArticlebioRxiv : the preprint server for biology2025

Esr1-Dependent Signaling and Transcriptional Maturation in the Medial Preoptic Area of the Hypothalamus Shapes the Development of Mating Behavior during Adolescence.

Koichi Hashikawa, Yoshiko Hashikawa, Brandy Briones, Kentaro Ishii, Yuejia Liu, Mark A Rossi, Marcus L Basiri, Jane Y Chen, Omar R Ahmad, Rishi V Mukundan and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Koichi HashikawaCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Yoshiko HashikawaCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Brandy BrionesCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Kentaro IshiiCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Yuejia LiuCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Mark A RossiCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Marcus L BasiriCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.ORCID 0000-0002-4829-7187
Jane Y ChenDepartment of Biochemistry, University of Washington, Seattle, WA 98195.ORCID 0000-0002-3986-8785
Omar R AhmadCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Rishi V MukundanCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Nathan L JohnstonCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Rhiana C SimonCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
James C SoetedjoCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Jason R SiputroCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.
Jenna A McHenryDepartment of Psychology & Neuroscience, Duke University, Durham, NC 27708.ORCID 0000-0001-7269-8856
Richard D PalmiterDepartment of Biochemistry, University of Washington, Seattle, WA 98195.ORCID 0000-0001-6587-0582
David R RubinowDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Larry S ZweifelDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195.ORCID 0000-0003-3465-5331
Garret D StuberCenter for the Neurobiology of Addiction, Pain, and Emotion, Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA 98195.ORCID 0000-0003-1730-4855

Funding

University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2019 to 2026
$13.0M
Neural circuit elements that orchestrate cue-reward associationsR37DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Garret D Stuber · 2017 to 2026
$4.5M
Lateral Hypothalamic Circuits for Feeding and ReinforcementR01DA038168 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2014 to 2025
$4.0M
Transcriptional, functional, and circuit profiling at single cell resolution of neuronal ensembles engaged by heroin relapseR01DA054317 · NIDA · UNIVERSITY OF WASHINGTON · PI FERGUSON, SUSAN MARIE, STUBER, GARRET D · 2021 to 2025
$2.7M
Midbrain Neural Circuit Elements That Underlie Cue-Reward AssociationsR01DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2012 to 2016
$1.6M
Disentangling discrete lateral hypothalamic circuits involved in feeding and obesityR00DK121883 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ROSSI, MARK ALLEN · 2021 to 2023
$735k
Disentangling discrete lateral hypothalamic circuits involved in feeding and obesityK99DK121883 · NIDDK · UNIVERSITY OF WASHINGTON · PI ROSSI, MARK ALLEN · 2019 to 2020
$181k
NIDA NIH HHS P30 DA048736NIDA NIH HHS R01 DA032750NIDA NIH HHS R01 DA038168NIDA NIH HHS R01 DA054317NIDA NIH HHS R37 DA032750NIDDK NIH HHS K99 DK121883NIDDK NIH HHS R00 DK121883
6 · The paper itself

Abstract

Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout the nervous system and periphery. In this study, we investigated the transcriptional dynamics of the medial preoptic area (MPOA), a critical region for reproductive behavior, using single-cell RNA sequencing (scRNAseq) and

Identifiers

PMID40060480
PMCPMC11888408

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.