Evidence map›Paper›PMID 40060478›Full record

ArticlebioRxiv : the preprint server for biology2025

Filament transport supports contractile steady states of actin networks.

Alfredo Sciortino, Magali Orhant-Prioux, Christophe Guerin, Louise Bonnemay, Yasuharu Takagi, James Sellers, Alexandra Colin, Manuel Théry, Laurent Blanchoin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alfredo SciortinoCytoMorpho Lab, Chimie Biologie Innovation, UMR8132, Université Paris Sciences et Lettres, Ecole Supérieure de Physique et Chimie Industrielles de la Ville de Paris, CEA, CNRS, Institut Pierre Gilles De Gennes, Paris 75005, France.
Magali Orhant-PriouxCytoMorpho Lab, Laboratoire de Physiologie Cellulaire et Végétale, UMR5168, Université Grenoble-Alpes, CEA, CNRS, INRA, Interdisciplinary Research Institute of Grenoble, Grenoble 38054, France.
Christophe GuerinCytoMorpho Lab, Laboratoire de Physiologie Cellulaire et Végétale, UMR5168, Université Grenoble-Alpes, CEA, CNRS, INRA, Interdisciplinary Research Institute of Grenoble, Grenoble 38054, France.
Louise BonnemayCytoMorpho Lab, Chimie Biologie Innovation, UMR8132, Université Paris Sciences et Lettres, Ecole Supérieure de Physique et Chimie Industrielles de la Ville de Paris, CEA, CNRS, Institut Pierre Gilles De Gennes, Paris 75005, France.
Yasuharu TakagiLaboratory of Molecular Physiology, Cell and Developmental Biology Center, National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, U.S.A.
James SellersLaboratory of Molecular Physiology, Cell and Developmental Biology Center, National, Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, U.S.A.
Alexandra ColinCytoMorpho Lab, Laboratoire de Physiologie Cellulaire et Végétale, UMR5168, Université Grenoble-Alpes, CEA, CNRS, INRA, Interdisciplinary Research Institute of Grenoble, Grenoble 38054, France.ORCID 0000-0002-9144-3282
Manuel ThéryCytoMorpho Lab, Chimie Biologie Innovation, UMR8132, Université Paris Sciences et Lettres, Ecole Supérieure de Physique et Chimie Industrielles de la Ville de Paris, CEA, CNRS, Institut Pierre Gilles De Gennes, Paris 75005, France.
Laurent BlanchoinCytoMorpho Lab, Chimie Biologie Innovation, UMR8132, Université Paris Sciences et Lettres, Ecole Supérieure de Physique et Chimie Industrielles de la Ville de Paris, CEA, CNRS, Institut Pierre Gilles De Gennes, Paris 75005, France.

Funding

EXPRESSION STUDIES OF OTHER UNCONVENTIONAL MYOSINSZ01HL004232 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SELLERS, JAMES R. · 2000 to 2008
$1.2M
THE ROLE OF CTGF IN SUBEPITHELIAL FIBROSIS IN ASTHMAK08HL004232 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RISHIKOF, DAVID C · 2000 to 2004
$625k
Intramural NIH HHS Z01 HL004232NHLBI NIH HHS K08 HL004232
6 · The paper itself

Abstract

In all eukaryotic cells, the actin cytoskeleton is maintained in a dynamic steady-state. Actin filaments are continuously displaced from cell periphery, where they assemble, towards the cell's center, where they disassemble. Despite this constant flow and turnover, cellular networks maintain their overall architecture constant. How such a flow of material can support dynamic yet steady cellular architectures remains an open question. To investigate the role of myosin-based forces in contractile steady-states of actin networks, we used a reconstituted

Identifiers

PMID40060478
PMCPMC11888238

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.