Evidence map›Paper›PMID 40060463›Full record

ArticlebioRxiv : the preprint server for biology2025

AggreBots: configuring CiliaBots through guided, modular tissue aggregation.

D Bhatttaram, K Golestan, X Zhang, S Yang, Z Gong, S L Brody, A Horani, V A Webster-Wood, A B Farimani, X Ren

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

D BhatttaramDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, USA.ORCID 0000-0002-1002-5506
K GolestanDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, USA.
X ZhangDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, USA.
S YangDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, USA.
Z GongDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, USA.
S L BrodyDepartment of Medicine, Washington University School of Medicine, St. Louis, USA.ORCID 0000-0002-0905-7527
A HoraniDepartment of Pediatrics, Washington University School of Medicine, St. Louis, USA.ORCID 0000-0002-5352-1948
V A Webster-WoodDepartment of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, USA.ORCID 0000-0001-6638-2687
A B FarimaniDepartment of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, USA.ORCID 0000-0002-2952-8576
X RenDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, USA.ORCID 0000-0003-3187-1311

Funding

Expedited Assessment of Environment-induced Respiratory Ciliopathies Leveraging Motile Apical-out Airway OrganoidsF31HL176100 · NHLBI · CARNEGIE-MELLON UNIVERSITY · PI Dhruv Bhattaram · 2024 to 2026
$99k
NHLBI NIH HHS F31 HL176100
6 · The paper itself

Abstract

Ciliated biobots, or CiliaBots, are a class of engineered multicellular tissues that are capable of self-actuated motility propelled by the motile cilia located on their exterior surface. Correlations have been observed between CiliaBot motility patterns and their morphology and cilia distribution. However, precise control of these structural parameters to generate desired motility patterns predictably remains lacking. Here, we developed a novel Aggregated CiliaBot (AggreBot) platform capable of producing designer motility patterns through spatially controlled aggregation of epithelial spheroids made from human airway cells (referred to as CiliaBot Building Blocks or CBBs), yielding AggreBots with configurable geometry and distribution of active cilia. Guided multi-CBB aggregation led to the production of rod-, triangle-, and diamond-shaped AggreBots, which consistently effected greater motility than traditional single-spheroid CiliaBots. Furthermore, CBBs were found to maintain internal boundaries post-aggregation through the combined action of pathways controlling cellular fluidity and tissue polarity. This boundary fidelity, combined with the use of CBBs with immotile cilia due to mutations in the

Identifiers

PMID40060463
PMCPMC11888266

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.