Evidence map›Paper›PMID 40060460›Full record

ArticlebioRxiv : the preprint server for biology2025

Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation.

Jimin Hu, Duc T Huynh, Denise E Dunn, Jianli Wu, Cindy Manriquez-Rodriguez, Qianyi E Zhang, Gabrielle A Hirschkorn, George R Georgiou, Tetsuya Hirata, Samuel A Myers and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jimin HuDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.
Duc T HuynhDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.
Denise E DunnDepartment of Radiation Oncology, Duke University School of Medicine, Durham, North Carolina, USA.
Jianli WuDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Cindy Manriquez-RodriguezLaboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, California, USA.
Qianyi E ZhangDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.
Gabrielle A HirschkornDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.
George R GeorgiouDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.
Tetsuya HirataDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.
Samuel A MyersLaboratory for Immunochemical Circuits, La Jolla Institute for Immunology, La Jolla, California, USA.
Scott R FloydDepartment of Radiation Oncology, Duke University School of Medicine, Durham, North Carolina, USA.
Jen-Tsan ChiDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-3433-903X
Michael BoyceDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-2729-4876

Funding

A consortium effort to translate therapies for neurological diseases via an ex vivo organotypic platformU01TR003715 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BALDWIN, ALBERT SIDNEY, FLORES, CATHERINE T · 2021 to 2024
$4.6M
Cell signaling through O-GlcNAc reader proteinsR01GM118847 · NIGMS · DUKE UNIVERSITY · PI BOYCE, MICHAEL S · 2016 to 2025
$2.8M
Elucidating the signaling and protein interaction networks of the O-GlcNAc transferase during embryonic stem cell state transitionsR35GM147554 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Samuel Anthony Myers · 2022 to 2026
$2.4M
Metabolic regulation of KLHL proteins through O-glycosylationR01NS111588 · NINDS · DUKE UNIVERSITY · PI BOYCE, MICHAEL S, CHI, JEN-TSAN ASHLEY · 2019 to 2022
$2.1M
NCATS NIH HHS U01 TR003715NIGMS NIH HHS R01 GM118847NIGMS NIH HHS R35 GM147554NINDS NIH HHS R01 NS111588
6 · The paper itself

Abstract

The 42-member Kelch-like (KLHL) protein family are adaptors for ubiquitin E3 ligase complexes, governing the stability of a wide range of substrates. KLHL proteins are critical for maintaining proteostasis in a variety of tissues and are mutated in human diseases, including cancer, neurodegeneration, and familial hyperkalemic hypertension. However, the regulation of KLHL proteins remains incompletely understood. Previously, we reported that two KLHL family members, KEAP1 and gigaxonin, are regulated by O-linked β-

Identifiers

PMID40060460
PMCPMC11888436

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.