Evidence map›Paper›PMID 40060432›Full record

ArticlebioRxiv : the preprint server for biology2025

Lysine-specific demethylase 1a is obligatory for gene regulation during kidney development.

Savithri Balasubramanian Kota, Satya K Kota

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Savithri Balasubramanian KotaNephrology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA; Current affiliation: Bayer U.S. LLC.
Satya K KotaDivision of Bone and Mineral Research, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Harvard University, Boston, USA.

Funding

Systematic elucidation of allele specific proteome at Imprint Control RegionsR01GM135377 · NIGMS · HARVARD MEDICAL SCHOOL · PI KOTA, SATYA K. · 2020 to 2024
$1.8M
Epigenetic regulation of skeletal patterning and morphogenesis during developmentK01AR069197 · NIAMS · HARVARD MEDICAL SCHOOL · PI KOTA, SATYA K. · 2016 to 2020
$563k
Retinoid mediated protection against AKI during agingR21AG047412 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KOTA, SAVITHRI BALASUBRAMANIAN · 2015 to 2016
$479k
NIAMS NIH HHS K01 AR069197NIA NIH HHS R21 AG047412NIGMS NIH HHS R01 GM135377
6 · The paper itself

Abstract

Histone methyltransferases and demethylases play crucial roles in gene regulation and are vital for proper functioning of multiple tissues. Lysine-specific histone demethylase 1A (Kdm1a), is responsible for the demethylation of specific lysines, namely K4 and K9, on histone H3. In this study, we investigated the functions of Kdm1a during mouse kidney development upon targeted deletion in renal progenitor cells. Loss of

Identifiers

PMID40060432
PMCPMC11888273

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.