ArticleFrontiers in endocrinology2025
The triglyceride-glucose index is a promising predictor for the risk of cardiovascular disease in the diabetic population aged ≥60 years in the United States: a retrospective cohort study from NHANES (2007-2016).
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Reconceptualizing Dyslipidemia: Diversity of Lipid Imbalances and Their Clinical Implications; A Narrative Review.Health science reports · 2026Article
- The association between triglyceride-glucose index and major adverse cardiovascular and cerebrovascular events in patients with heart failure.Journal of health, population, and nutrition · 2026Article
- The association between insulin resistance indices and the occurrence of major adverse cardiovascular events in patients with premature myocardial infarction: a prospective cohort study.Frontiers in nutrition · 2026Article
- Association of the Triglyceride Glucose Index and Epicardial Adipose Tissue with Type 2 Diabetes Mellitus Complicated by Coronary Atherosclerotic Heart Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Association between triglyceride-glucose index and heart failure in patients with type 2 diabetes mellitus: a cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Correlation of the triglyceride-glucose index with major adverse cardiovascular events in type 2 diabetes mellitus patients with acute myocardial infarction combined with HFpEF.Frontiers in endocrinology · 2025Article
- Association Between the Triglyceride-Glucose Index and All-Cause Mortality Among Patients with Diabetes and Chronic Kidney Disease: A Retrospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
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Abstract
Background: The predictive value of triglyceride-glucose index (TyG) for cardiovascular disease (CVD) in the US elderly diabetic patients is ambiguous. This study aimed to investigate the association between TyG index and the risk of CVD in an older US population with diabetes. Methods: The study examined data from the 2007-2016 National Health and Nutrition Examination Survey (NHANES). Univariate and multivariate regression analysis models were obtained to explore the association between baseline TyG index and the risk of CVD. Non-linear association were investigated using restricted cubic spline (RCS) regression. Subgroup analyses and interaction tests were constructed and a sensitivity analyses was carried out. The 10 - year CVD risk were evaluated via the Framingham Risk Score (FRS). Mediation analysis explored the mediating role of glycated hemoglobin in the above relationships. Results: A total of 2987 subjects were included (977 CVD patients and 2010 non-CVD persons). CVD patients had higher TyG values (9.01 ± 0.58 vs. 8.94 ± 0.56, P=0.003), and the prevalence of CVD increased with TyG index (P=0.015). In a multifactorial regression model with gradual adjustment for all covariates, the risk of CVD associated with TyG increased by 48.0% in the highest quartile group (OR 1.480, 95% Cl 1.171-1.871, P=0.001). The RCS curves showed a U-shaped association between TyG index and CVD risk (P for overall=0.013, P for nonlinear=0.043). Subgroup analyses showed that in the highest quartile group, individuals with body mass index (BMI) ≥24 kg/m Conclusion: In a sample of US elderly diabetic patients, there is the U-shaped association of TyG index with CVD risk. This implies that TyG index can be regarded as an extremely important predictor for screening people at high risk of cardiovascular disease among elderly diabetic patients.
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