Evidence map›Paper›PMID 40060229›Full record

ArticleIranian journal of pathology2025

The Association Between RACK1 Gene Polymorphisms rs1279736 and rs3756585 in Uterine Cervical Cancer with the Risk Factor of HPV: A Focus on Squamous Cell Carcinoma (SCC).

Maryam Fekri Soofi Abadi, Fatemeh Hashemi, Saeedeh Shojaeepour, Sahar Amirpour-Rostami, Mohammad Reza Zangouey, Sara Pourshaikhali, Fatemeh Pouya, Shahriar Dabiri

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Article in Iranian journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Maryam Fekri Soofi AbadiPathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Fatemeh HashemiDepartment of Biochemistry & Molecular Biology, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Saeedeh ShojaeepourDepartment of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Sahar Amirpour-RostamiPharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Mohammad Reza ZangoueyPathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Sara PourshaikhaliPathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Fatemeh PouyaDepartment of Anatomy, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Shahriar DabiriPathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Objective: Cervical cancer is the second most common malignancy among women worldwide. The Receptor for Activated C Kinase 1 (RACK1) has a key role in regulating the pathways of cell signaling, angiogenesis, cell migration, invasion, and metastasis. This study investigated the association of polymorphisms rs1279736 and rs3756585 with cervical cancer. Methods: In this study, 100 LB pap-smear and paraffin block samples of cervical squamous carcinoma associated with Human Results: The rs1279736 polymorphism shows that the chance of cervical cancer in individuals with CA and AA genotypes is 3.772 and 1.852 times that of CC genotypes, respectively. This suggests that the A allele is involved in developing cervical cancer ( Conclusion: The present study was conducted for the first time. Our results showed that two polymorphisms are significantly associated with cervical cancer.

Indexed as

Cervical cancerGenetic polymorphismsHPVRACK1

Identifiers

PMID40060229
PMCPMC11887637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.