Evidence map›Paper›PMID 40060221›Full record

ReviewIranian journal of pathology2025

Vacuolating Cytotoxin A (VacA) and Extracellular Vesicles in

Seyedeh Faride Alavi Rostami, Mansoor Khaledi, Fatemeh Dalilian, Mahtab Mehboodi, Atefeh Akbari, Milad Shahini Shams Abadi, Pouria Khodaei Ataloo, Zeinab Mohsenipour, Samad Rastmanesh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Iranian journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The microbiota-proteostasis axis: implications in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Seyedeh Faride Alavi RostamiDepartment of Microbiology, Faculty of Biological Sciences, Islamic Azad University Tehran-North Branch, Tehran, Iran.
Mansoor KhalediDepartment of Microbiology and Immunology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Fatemeh DalilianDepartment of Microbiology, Mashhad University of Bacic science, Mashhad, Iran.
Mahtab MehboodiDepartment of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Atefeh AkbariDepartment of Microbiology, Faculty of Science, Qom branch, Islamic Azad University, Qom, Iran.
Milad Shahini Shams AbadiDepartment of Microbiology and Immunology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Pouria Khodaei AtalooDepartment of Microbiology, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran.
Zeinab MohsenipourDepartment of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Samad RastmaneshDepartment of Bacteriology and Virology, School of Medicine, Tabriz University of Medical Science, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are cell-derived vesicles that play a critical role in host-pathogen interactions, facilitating intercellular communication and transporting both pathogen- and host-derived molecules during infection spread. To regulate their environment, for instance, by modulating innate and adaptive inflammatory immune responses, pathogens may alter the composition of EVs produced by infected cells. Gastric cancer is one of the leading causes of cancer-related deaths worldwide, and Helicobacter pylori infection is considered a significant risk factor for its development. This cancer is characterized by significant inflammation mediated by EVs generated from infected host cells. H. pylori contributes substantially to inflammation, promoting disease progression. Moreover, H. pylori produces and releases vesicles known as outer membrane vesicles (H. pylori-OMVs), which contribute to the shrinkage and cellular transformation of the gastric epithelium. Although the vacuolating cytotoxin A (VacA) plays a critical role in pathogenesis, its association with EVs in H. pylori has not been previously addressed. Understanding the roles of extracellular vesicles and VacA during H. pylori infection-whether they benefit the host or the pathogen-could pave the way for new treatment approaches. This review briefly discusses the role of VacA and extracellular vesicles in the growth and pathogenesis of

Indexed as

AutophagyCell signalingDisease developmentExtracellular vesiclesHelicobacter diseaseImmune cells

Identifiers

PMID40060221
PMCPMC11887638

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.