Evidence map›Paper›PMID 40060198›Full record

ArticleHRB open research2024

Protocol for the development of an intervention to improve the use of Point-of-caRE DiagnostICs in the management of respiraTOry tRact infectionS in primary care (the PREDICTORS study).

Joseph O'Shea, Carmel Hughes, Gerard Molloy, Cathal Cadogan, Akke Vellinga, Tom Fahey, Gail Hayward, Paul Ryan, Aoife Fleming, Eimear Morrissey and 2 more

Abstract read
In one paragraph

Article in HRB open research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joseph O'SheaSchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Leinster, Ireland.ORCID https://orcid.org/0000-0001-9860-9807
Carmel HughesSchool of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland, UK.
Gerard MolloySchool of Psychology, College of Arts, Social Sciences and Celtic Studies, University of Galway, Galway, County Galway, Ireland.ORCID https://orcid.org/0000-0002-7718-9898
Cathal CadoganSchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Leinster, Ireland.ORCID https://orcid.org/0000-0002-8778-0112
Akke VellingaSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0002-6583-4300
Tom FaheyDepartment of General Practice, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID https://orcid.org/0000-0002-5896-5783
Gail HaywardDepartment of Primary Care Health Sciences, University of Oxford, Oxford, England, UK.
Paul RyanIrish College of General Practitioners, Dublin, Ireland.
Aoife FlemingSchool of Pharmacy, University College Cork, Cork, Ireland.
Eimear MorrisseyCentre for Health Research Methodology, School of Nursing and Midwifery, University of Galway, Galway, Ireland.ORCID https://orcid.org/0000-0003-1452-6145
Laura CookeThe Irish Platform for Patient Organisations, Science, and Industry (IPPOSI), Dublin, Ireland.
Cristin RyanSchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Leinster, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Antimicrobial resistance is a significant global health challenge, exacerbated by inappropriate antibiotic prescribing, particularly in primary care where up to 50% of antibiotic prescriptions prescribed by general practitioners (GPs) and dispensed by community pharmacists (CPs) are deemed inappropriate. Respiratory tract infections (RTIs) are among the most common conditions leading to GP consultations and subsequent antibiotic prescribing, much of which is inappropriate as most RTIs are viral in nature or self-limiting bacterial infections. Point-of-care tests (POCTs) have emerged as tools to improve the diagnosis and appropriate treatment of RTIs. Objective: This study aims to develop and test an intervention to improve the use of POCTs in managing RTIs involving GPs and CPs in Irish primary care, following the UK's Medical Research Council's (MRC) framework for complex intervention development, involving five work-packages (WPs). Methods: WP1 involves creating best practice guidance for using POCT in managing RTIs, informed by a scoping review and validated with an expert Delphi panel. This guidance will be used to define target behaviour(s) for GPs and CPs related to POCT use. WP2 explores GP and CP perceived barriers and facilitators to these behaviours using the Theoretical Domains Framework, mapping influential domains to Behaviour Change Techniques to develop draft interventions. WP3 gathers patients' perspectives on using POCTs for RTIs. In WP4, a task group will review and finalise the intervention(s). They will consider patients' perspectives from WP3 and assess feasibility of the intervention(s). WP5 involves a proof-of-concept study to test the feasibility of the newly developed intervention(s). Conclusion: A theoretically informed intervention(s) for using POCT(s) in the management of RTIs in primary care in Ireland will be developed and tested in a proof-of-concept study, following MRC guidance. Further refinement and larger studies will be needed to determine its effectiveness before widespread implementation.

Indexed as

antibioticsantimicrobial resistancecommunity pharmacistgeneral practitionerPoint-of-care testprimary carerespiratory tract infection

Identifiers

PMID40060198
PMCPMC11890267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.