ReviewHeart rhythm O22025
Antithrombotic therapy in atrial flutter: To anticoagulate or not, that is the question.
Review in Heart rhythm O2, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- State of the Journal 2026.Heart rhythm O2 · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrial fibrillation (AF) represents an arrhythmia fraught with significant morbidity, mortality, and financial burden for the health care system. Less attention is given to atrial flutter (AFL), which may occur as a stand-alone arrhythmia or coexist with AF in the same patient. Moreover, it is known that AF frequently develops after AFL ablation. Despite different pathophysiologies of AF and AFL, current guidelines provide identical indications for anticoagulation therapy in both arrhythmias, given the lack of trials in patients with AFL. This study attempts at providing an up-to-date literature review on the thromboembolic risk profile in AFL, focusing on differences between AFL and AF. Echocardiographic studies showed that the presence of spontaneous echocardiographic contrast (SEC) and thrombus are much less prevalent in patients with AFL than in those with AF. Patients with AFL had overall better left atrial appendage (LAA) function and lower coagulation marker levels than did patients with AF. Observational studies showed a significantly lower risk of stroke in patients with AFL than in those with AF. One study found a significantly higher ischemic stroke incidence in the AFL cohort only at CHA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.