Evidence map›Paper›PMID 40060143›Full record

ArticleBioactive materials2025

3D-printed PCL scaffolds combined with injectable sodium alginate/magnesium-doped mesoporous bioactive glass nanosphere hydrogel for meniscus regeneration: In vitro, In vivo, and multiomics-based therapeutic analyses.

Hao Li, Yongkang Yang, Tianze Gao, Runmeng Li, Chao Wang, Xue Wang, Tianyuan Zhao, Qinyu Tian, Zhixing Zhang, Ruiyang Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. [Advances in immunomodulatory strategies for meniscal regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hao LiSchool of Medicine, Nankai University, Tianjin, 300071, China.
Yongkang YangSchool of Medicine, Nankai University, Tianjin, 300071, China.
Tianze GaoSchool of Medicine, Nankai University, Tianjin, 300071, China.
Runmeng LiSchool of Medicine, Nankai University, Tianjin, 300071, China.
Chao WangInstitute of Orthopedics, the First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Xue WangAnhui Province Engineering Research Center for Dental Materials and Application, School of Stomatology, Wannan Medical College, No.22, West Wenchang Road, Yijiang District, Wuhu, 241002, China.
Tianyuan ZhaoInstitute of Orthopedics, the First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Qinyu TianInstitute of Orthopedics, the First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Zhixing ZhangSchool of Medicine, Nankai University, Tianjin, 300071, China.
Ruiyang ZhangSchool of Medicine, Nankai University, Tianjin, 300071, China.
Quanyi GuoSchool of Medicine, Nankai University, Tianjin, 300071, China.
Zhiguo YuanInstitute of Orthopedics, the First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Peifu TangSchool of Medicine, Nankai University, Tianjin, 300071, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meniscal injury presents a formidable challenge and often leads to functional impairment and osteoarthritic progression. Meniscus tissue engineering (MTE) is a promising solution, as conventional strategies for modulating local immune responses and generating a conducive microenvironment for effective tissue repair are lacking. Recently, magnesium-containing bioactive glass nanospheres (Mg-BGNs) have shown promise in tissue regeneration. However, few studies have explored the ability of Mg-BGNs to promote meniscal regeneration. First, we verified the anti-inflammatory and fibrochondrogenic abilities of Mg-BGNs in vitro. A comprehensive in vivo evaluation of a rabbit critical-size meniscectomy model revealed that Mg-BGNs have multiple effects on meniscal reconstruction and effectively promote fibrochondrogenesis, collagen deposition, and cartilage protection. Multiomics analysis was subsequently performed to further explore the mechanism by which Mg-BGNs regulate the regenerative microenvironment. Mechanistically, Mg-BGNs first activate the TRPM7 ion channel through the PI3K/AKT signaling pathway to promote the cellular function of synovium-derived mesenchymal stem cells and then activate the PPARγ/NF-κB axis to modulate macrophage polarization and inflammatory reactions. We demonstrated that Mg

Indexed as

Immunomodulatory microenvironmentMeniscus regenerationMg-BGNsMultiomics analysisTissue engineering

Identifiers

PMID40060143
PMCPMC11889361

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.