ArticleBioactive materials2025
Multiscale mechanical-adapted hydrogels for the repair of intervertebral disc degeneration.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction.Bioactive materials · 2027Review
- Dual-mode light/ROS-responsive microneedles enable adaptive nitric oxide therapy across tissue depths.Materials today. Bio · 2026Article
- Blood-Coagulation-Inspired Dual-Network Hydrogel with Delayed In Situ Gelation for Enhancing Intradiscal Diffusion and Promoting Intervertebral Disc Degeneration Repair.Advanced healthcare materials · 2026Article
- A sequential and synergistic release sacrificial microgels scaffold for endometrial niche reprogramming and fertility restoration.Materials today. Bio · 2026Article
- High-performance hydrogels in orthopedics: Structural design, performance tuning, and clinical potential.Materials today. Bio · 2026Review
- A ROS and pH dual - responsive hydrogel-nanoparticle system restores intervertebral disc and alleviates related pain by modulating senescence and panoptosis of nucleus pulposus cells.Materials today. Bio · 2026Article
- Ultrasound-responsive CPS piezoelectric hydrogel synergistically repairs annulus fibrosus defects through immune reprogramming and cell recruitment.Materials today. Bio · 2026Article
- SOD1 lactylation impair its enzymatic activity by conformational change to aggravate intervertebral disc degeneration.Nature communications · 2026Article
- Thermo-responsive, on-demand adhesive and tissue-conformal hydrogel electrodes for organ repair and brain-computer interfaces.Materials today. Bio · 2026Article
- The Biomechanical Landscape of Lumbar Disc Herniation: Mechanobiological Insights Into Injury and Regeneration.Neurospine · 2026Review
- From molecular regulation to tissue repair: hydrogels in the fight against intervertebral disc degeneration.Annals of medicine · 2025Review
- Anti-Swelling Hydrogel Combined With Nucleus Pulposus Cell Exosomes and Senolytic Drugs Efficiently Repair Intervertebral Disc Degeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multimodal mechanoregulation strategies towards tissue regeneration.Mechanobiology in medicine · 2025Review
- DEPTOR regulates nucleus pulposus cell senescence through the mTORC1/S6K1/ATG1 pathway to alleviate intervertebral disk degeneration.Cell death discovery · 2025Article
- [Research progress of hydrogel-based growth factors for treatment of intervertebral disc degeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- Catalyst-modulated hydrogel dynamics for decoupling viscoelasticity and directing macrophage fate for diabetic wound healing.Bioactive materials · 2025Article
- Tissue engineering strategies for treating intervertebral disc degeneration.Frontiers in bioengineering and biotechnology · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleus pulposus (NP) tissue engineering brings new hope in the repair of intervertebral disc degeneration (IVDD). IVDD is often accompanied by multiscale changes in the mechanical microenvironment, including the changes of mechanical property of collagen fibril, NP tissue, and mechanical instability of spine. In this study, a multiscale mechanically-adapted strategy is proposed to promote NP repair. To achieve this goal, a viscoelastic-adapted dual-network hydrogel (PVA-DN) is constructed. The hydrogel with multiscale tunable viscoelasticity and dynamic compression condition is used to meet the multiscale mechanical requirements of NP regeneration. The results show that the viscoelastic hydrogel promotes the proliferation, migration and adhesion of nucleus pulposus cell (NPC) as well as the secretion of NP-specific extracellular matrix. RNA-seq results show that it attenuates the inflammatory microenvironment by inhibiting the IL-17 signaling pathway. Appropriate dynamic compression applied to the viscoelastic scaffold further promotes the physiological function of NPC, and the viscoelasticity of hydrogel protects against NPC damage induced by excessive compression. Animal experiments demonstrate that the viscoelastic hydrogel effectively restores disc mechanical function and delays disc degeneration in rats. Findings from this study highlight that the multiscale mechanically-adapted strategy is effective in the repair of IVDD.
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