ArticleBioactive materials2025
Primary and Re-exposure effects of D-enantiomeric peptide on metabolism, diversity, and composition of oral biofilms at different stages of recovery.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- An innate defense regulator peptide modulates the inflamed pulp microenvironment and promotes pulp repair.Bioactive materials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The persistence of bacteria in the root canal system is the primary cause of recurrent apical periodontitis. The adaptability of residual bacteria to changing environmental conditions is a key survival strategy of biofilms, often leading to endodontic treatment failure. DJK-5 is a protease-resistant, broad-spectrum D-enantiomeric peptide that degrades or prevents the accumulation of guanosine penta- and tetraphosphates, which are important for biofilm formation. We evaluated the effects of primary antimicrobial agents and nutrient conditions on the recovery, metabolism, diversity, and composition of oral biofilms, and investigated how these factors affect the efficacy of DJK-5 and chlorhexidine (CHX) during re-exposure. Primary irrigants and nutrient conditions significantly influenced biofilm recovery, metabolic activity, diversity, and composition. Biofilm recovery was slower in nutrient-poor groups compared to nutrient-rich ones, and nutrient availability had the greatest effect on shaping both the diversity and composition of the biofilms. Water and DJK-5 groups showed similar biofilm diversity trends, while CHX generally led to lower diversity. Results indicate that primary irrigants and nutrient conditions significantly impact biofilm composition, diversity, and recovery. However, these changes did not compromise DJK-5's effectiveness in killing of biofilm microbes during re-exposure of recovered biofilms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.