Evidence map›Paper›PMID 40060117›Full record

ArticleHemaSphere2025

Age- and gender-specific molecular characteristics of diffuse large B-cell lymphoma: Results from clinical trials of the DSHNHL/GLA.

Katrin S Kurz, Sophia Steinlein, Markus Kreuz, Marita Ziepert, Annette M Staiger, Thomas F E Barth, Peter Möller, Heinz-Wolfram Bernd, Alfred C Feller, Julia Richter and 11 more

Abstract read
In one paragraph

Article in HemaSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Katrin S KurzDepartment of Clinical Pathology Robert-Bosch-Krankenhaus Stuttgart Germany.
Sophia SteinleinDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology Stuttgart and University of Tübingen Tübingen Germany.
Markus KreuzInstitute for Medical Informatics, Statistics, and Epidemiology Universität Leipzig Leipzig Germany.
Marita ZiepertInstitute for Medical Informatics, Statistics, and Epidemiology Universität Leipzig Leipzig Germany.
Annette M StaigerDepartment of Clinical Pathology Robert-Bosch-Krankenhaus Stuttgart Germany.
Thomas F E BarthInstitute of Pathology Universitätsklinikum Ulm Ulm Germany.
Peter MöllerInstitute of Pathology Universitätsklinikum Ulm Ulm Germany.
Heinz-Wolfram BerndHematopathology Lübeck Germany.
Alfred C FellerHematopathology Lübeck Germany.
Julia RichterInstitute of Pathology, Hematopathology Section and Lymph Node Registry, Universitätsklinikum Schleswig-Holstein, Campus Kiel Kiel Germany.
Wolfram KlapperInstitute of Pathology, Hematopathology Section and Lymph Node Registry, Universitätsklinikum Schleswig-Holstein, Campus Kiel Kiel Germany.ORCID 0000-0001-7208-4117
Harald SteinPathodiagnostik Berlin Germany.
Sylvia HartmannInstitute of Pathology, Universitätsklinikum Frankfurt Frankfurt Germany.
Martin-Leo HansmannInstitute of Pathology, Universitätsklinikum Frankfurt Frankfurt Germany.
Lorenz TrümperDepartment of Hematology and Oncology Georg-August Universität Göttingen Germany.
Markus LoefflerInstitute for Medical Informatics, Statistics, and Epidemiology Universität Leipzig Leipzig Germany.
Norbert SchmitzDepartment of Medicine A University Hospital Münster Münster Germany.
Andreas RosenwaldInstitute of Pathology Universität Würzburg Würzburg Germany.
German OttDepartment of Clinical Pathology Robert-Bosch-Krankenhaus Stuttgart Germany.
Heike HornDepartment of Clinical Pathology Robert-Bosch-Krankenhaus Stuttgart Germany.ORCID 0000-0002-2933-005X
DSHNHL/GLA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. Despite a high cure rate, too many patients show refractory (ref) or relapsed (rel) disease. This study examines the frequency of recurring gene mutations and their interplay with well-known biomarkers in female and male patients between 18 and 80 years with ref/rel DLBCL compared to patients with complete remission (CR) to identify biological risk factors associated with treatment response, using cohorts of R-CHOP-like treated DLBCL enrolled in clinical trials of the DSHNHL. The biomarker profile of patients differed between younger and elderly patients with ref/rel DLBCL, with a higher frequency of

Identifiers

PMID40060117
PMCPMC11888124

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.