Trial reportNeuropsychiatric disease and treatment2025
Optimal Treatment of Magnetic Seizure Therapy (MST) in Patients with Clozapine-Resistant Schizophrenia (CRS).
Trial report in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Beyond Clozapine Failure: Precision Approach and Palliative Psychiatry in Ultra-Treatment-Resistant Schizophrenia.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The study aims to compare the clinical efficacy and cognitive side effect of magnetic seizure therapy (MST) and modified electroconvulsive therapy (MECT) on clozapine resistant schizophrenia (CRS). Methods: Sixteen patients with CRS were enrolled in this randomized, parallel-group, controlled clinical trial. Patients were randomly allocated to receive 10 sessions of add-on MST or MECT over 4 weeks (1:1 ratio) and continued clozapine therapy during the study. Efficacy and neurocognition were assessed at baseline, 4-week and 8-week follow-up. Results: (1) Clinical efficacy: MST significantly improved symptoms of schizophrenia from baseline to 4 weeks, as shown in PANSS total (p = 0.009), PANSS positive (p = 0.026), PANSS negative (p = 0.031) and PANSS general psychopathology (p = 0.023); we also observed significant reductions in PANSS total (p = 0.049) and PANSS positive (p = 0.037) at 8-week follow-up. MECT group also witnessed clinical improvement from baseline to 4-week in PANSS total (p = 0.035) and PANSS positive (p = 0.001); significant reduction in PANSS positive was also observed at 8-week follow-up (p = 0.041). From baseline to 8 weeks, PANSS negative had greater reduction in MST group compared with MECT group (p = 0.042). (2) Neurocognition: Pre-and post-treatment data showed no significant cognitive adverse effects in both groups. Immediate memory is better in patients who received MST than MECT at 4-week follow-up (p = 0.030). Conclusion: In this pilot study, MST and MECT equally improved positive symptoms of CRS, while MST was more effective in relieving negative symptoms. Evidence showed negligible cognitive side effects in MST, with less adverse effect on immediate memory than MECT. As a promising alternative to MECT, MST requires further research in larger clinical population.
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