Evidence map›Paper›PMID 40059987›Full record

ArticleBiofilm2025

In vivo efficacy of a refillable intrawound drug delivery device in a sheep model of biofilm-compromised open fracture-related infection.

Dustin Williams, David Rothberg, Walker Kay, Lisa Nehring, Robert Falconer, Richard Tyler Epperson, Brooke Kawaguchi, Carolyn Ardizzone, Brian Barnum, Nicholas Ashton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biofilm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Refillable silicone pump with precise switching for timed therapeutic delivery.Frontiers in bioengineering and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dustin WilliamsDepartment of Orthopaedics, University of Utah, Salt Lake City, UT, USA.
David RothbergDepartment of Orthopaedics, University of Utah, Salt Lake City, UT, USA.
Walker KayNoorda College of Osteopathic Medicine, Provo, UT, USA.
Lisa NehringRocky Vista University School of Osteopathic Medicine, St. George, UT, USA.
Robert FalconerDepartment of Orthopaedics, University of Utah, Salt Lake City, UT, USA.
Richard Tyler EppersonDepartment of Orthopaedics, University of Utah, Salt Lake City, UT, USA.
Brooke KawaguchiDepartment of Orthopaedics, University of Utah, Salt Lake City, UT, USA.
Carolyn ArdizzoneSchool of Medicine, University of New Mexico, Albuquerque, NM, USA.
Brian BarnumPurgo Scientific, South Jordan, UT, USA.
Nicholas AshtonDepartment of Orthopaedics, University of Utah, Salt Lake City, UT, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Open fracture-related infection challenges persist in healthcare. From the time open fractures were defined ∼50 years ago, infection rates have gone essentially unchanged. Contributing factors include compromised vasculature, biofilm, and stalled innovations in treatment and prophylaxis. In this study, we engineered and tested the efficacy of a refillable drug delivery device, the Purgo Pouch (Pouch), that sustains local, high dose intrawound antibiotic concentrations in wound sites. We hypothesized that it would manage biofilm-compromised open fracture-related infection better than clinical standards of care. Therapies were tested in a unique sheep model of long bone open fracture-related infection with compromised tissue and biofilm inocula of methicillin-resistant

Indexed as

BiofilmInfectionOpen fractureOrthopedicSheep modelSustainable drug delivery

Identifiers

PMID40059987
PMCPMC11889977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.