Evidence map›Paper›PMID 40059898›Full record

ArticleWorld journal of clinical pediatrics2025

Psycho-gastroenterological profile of an Italian population of children with disorders of gut-brain interaction: A case-control study.

Valentina Giorgio, Ilaria Venezia, Licia Pensabene, Elisa Blasi, Donato Rigante, Paolo Mariotti, Giuseppe Stella, Gaia Margiotta, Giovanna Quatrale, Giuseppe Marano and 3 more

Abstract read
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In one paragraph

Article in World journal of clinical pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valentina GiorgioPediatric Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Ilaria VeneziaChild Neuropsychiatry Unit, ASST Santi Paolo e Carlo, San Paolo Hospital, Milan 20142, Italy.
Licia PensabeneDepartment of Medical and Surgical Sciences, Pediatric Unit, University Magna Graecia, Catanzaro 88100, Italy.
Elisa BlasiPediatric Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Donato RigantePediatric Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Paolo MariottiChild Neuropsychiatry Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Giuseppe StellaPediatric Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Gaia MargiottaPediatric Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Giovanna QuatralePediatric Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Giuseppe MaranoUnit of Psychiatry, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome 00168, Italy.
Marianna MazzaUnit of Psychiatry, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome 00168, Italy.
Antonio GasbarriniDepartment of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome 00168, Italy.
Eleonora GaetaniDepartment of Medical and Surgical Sciences, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisorders of gut-brain interaction (DGBI) are common, but knowledge about their physiopathology is still poor, nor valid tools have been used to evaluate them in childhood.

aimTo develop a psycho-gastroenterological questionnaire (PGQ) to assess the psycho-gastroenterological profile and social characteristics of a pediatric population with and without DGBI.

methodsOne hundred and nineteen Italian children (age 11-18) were included: 28 outpatient patients with DGBI (Rome IV criteria) and 91 healthy controls. They filled the PGQ, faces pain scale revised (FPS-R), Bristol stool chart, gastrointestinal symptoms rating scale, state-trait anxiety inventory, Toronto alexithymia scale 20, perceived self-efficacy in the management of negative emotions and expression of positive emotions (APEN-G, APEP-G), irritable bowel syndrome-quality of life questionnaire, school performances, tobacco use, early life events, degree of digitalization.

resultsCompared to controls, patients had more medical examinations (35% of them went to the doctor more than five times), a higher school performance (23%

conclusionPediatric outpatients with DGBI had a higher prevalence of early life events, a lower quality of life, more medical examinations rising health care costs, lower anxiety levels.

Indexed as

Disorders of gut-brain interactionFunctional gastrointestinal disordersGut-brain axisPediatric patientsPsycho-gastroenterological profileRome IV criteria

Identifiers

PMID40059898
PMCPMC11686583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.