Evidence map›Paper›PMID 40059894›Full record

ArticleWorld journal of clinical pediatrics2025

Cardiovascular involvement in multisystem inflammatory syndrome in children and midterm follow-up from a pediatric tertiary center in India.

Poovazhagi Varadarajan, Ritchie Sharon Solomon, Seenivasan Subramani, Ramesh Subramanian, Gomathy Srividya, Elilarasi Raghunathan

Abstract read
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Article in World journal of clinical pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Post-MIS-C cardiovascular outcomes: a systematic review.European journal of pediatrics · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Poovazhagi VaradarajanDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600003, Tamil Nādu, India.
Ritchie Sharon SolomonDepartment of Pediatric Cardiology, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600003, Tamil Nādu, India. ritchie_sharon@yahoo.com.
Seenivasan SubramaniDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600003, Tamil Nādu, India.
Ramesh SubramanianDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600003, Tamil Nādu, India.
Gomathy SrividyaDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600003, Tamil Nādu, India.
Elilarasi RaghunathanDepartment of Pediatrics, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600003, Tamil Nādu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn multisystem inflammatory syndrome in children (MIS-C) with coronavirus disease 2019, there was paucity of data from low-income and middle-income countries on cardiovascular involvement and its longitudinal outcomes. We planned to estimate the pattern of cardiovascular involvement among children with MIS-C and its mid-term outcomes.

aimTo determine association between cardiovascular abnormalities and clinical and laboratory parameters. To study the time-line for resolution of various abnormalities.

methodsIn this prospective study done in a tertiary care hospital, 270 were recruited from June 2020 to January 2022. Baseline demographic data and clinical presentation were recorded. Laboratory parameters and echocardiography were done at admission. Follow-up was done at 2 weeks, 3 months, 6 months and 1 year after diagnosis. Descriptive statistics were used for parametric and non-parametric data. Risk factors were identified by multivariate regression analysis.

resultsThe 211 (78.2%) had cardiac involvement and 102 needed intensive care unit (ICU) admission. Cardiovascular abnormalities observed were shock 123 (45.6%), coronary dilatation 28 (10.4%), coronary aneurysm 77 (28.5%), left ventricular (LV) dysfunction 78 (29.3%), mitral regurgitation (MR) 77 (28.5%) and pericardial effusion 98 (36.3%). Coronary artery aneurysm/dilatation during follow-up at 2 weeks and 1 year were 25.7% and 0.9% respectively. Multivariate regression analysis revealed breathlessness [odds ratio (OR) = 3.91, 95%CI: 1.25-12.21,

conclusionSignificant number of children with MIS-C had cardiovascular involvement contributing to higher ICU management. Although shock resolved quickly, resolution of ventricular function and coronary abnormalities were slower, and hence warrants a structured long-term follow-up protocol.

Indexed as

CardiovascularCoronary artery aneurysmLeft ventricular dysfunctionMidterm follow-upMultisystem inflammatory syndrome in childrenShock

Identifiers

PMID40059894
PMCPMC11686581

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