Trial reportAnnals of medicine2025
Impact of transcutaneous auricular vagus nerve stimulation on postoperative pain in patients undergoing perianal surgery: a randomized trial.
Trial report in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Effect of transcutaneous auricular vagus nerve stimulation on postoperative pain in patients undergoing thoracoscopic partial lung resection: a randomized, double-blind, controlled clinical trial.Annals of medicine · 2026Trial
- Transcutaneous Auricular Neurostimulation Modulates Pain Perception in Survivors of Stroke With Chronic Upper-Extremity Pain: A Randomized, Sham-Controlled Pilot Study.Neuromodulation : journal of the International Neuromodulation Society · 2026Trial
- Transcutaneous Auricular Vagus Nerve Stimulation and Pectoral-Intercostal Fascial Block for the Prevention of Chronic Postsurgical Pain in Elderly Patients Undergoing Off-Pump Coronary Artery Bypass Grafting: A 2×2 Factorial, Double-Blinded, Randomized Clinical Trial.Clinical interventions in aging · 2026Trial
- Effects of Ropivacaine-Based Thoracic Paravertebral Block versus Erector Spinae Plane Block on Quality of Recovery in Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation for Postoperative Pain Relief in Patients Undergoing Elective Laparoscopic Gastrointestinal Tumor Surgery.Pain and therapy · 2026Article
- Transcutaneous auricular vagus nerve stimulation for postoperative pain: a protocol for a systematic review and meta-analysis.BMJ open · 2026Article
- Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation for Postoperative Pain: A Systematic Review and Meta-Analysis.Journal of pain research · 2026Review
- Transcutaneous auricular vagus nerve stimulation after cesarean delivery: current evidence and trial design priorities.Frontiers in medicine · 2026Review
- Transauricular Vagus Nerve Stimulation for Postoperative Analgesia following Arthroscopic Shoulder Surgery: A Double-Blind, Randomized, Placebo-Controlled Trial.Pain and therapy · 2025Article
- Case Report: Effect of transcutaneous auricular vagus nerve stimulation on acute pain after external fixation for bilateral open tibiofibular fractures.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative pain in patients following perianal surgery.
methods96 patients were randomly assigned to either the taVNS group or the sham stimulation group. Patients received stimulation once 30 min before the operation and once more 24 h after the operation, with each session lasting 30 min. The VAS scores were recorded at 2, 6, 24, 48, and 72 h, as well as 7 days postoperatively. Data were collected on the first change of dressing, the first defecation, the frequency of supplementary analgesia, and the occurrence of adverse reactions. Patient satisfaction was assessed at the time of hospital discharge.
resultsThe VAS scores of patients in the taVNS group were significantly lower than those in the sham stimulation group at 2, 6, 24, 48, and 72 h postoperatively, at the time of the first dressing change, and at the time of the first defecation (
conclusiontaVNS effectively alleviates postoperative pain in patients undergoing perianal surgery without increasing the risk of complications.
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