ArticleTransfusion2025
Nationwide estimates of potential lives saved with prehospital blood transfusions.
Article in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Unequal access to timely care: Geographic variation in prehospital time among injured patients at risk of hemorrhagic shock.Transfusion · 2026Article
- Mobile triage units for abdominal trauma in sub-Saharan Africa: current evidence, implementation barriers, and strategies for scale-up.Annals of medicine and surgery (2012) · 2026Review
- Prehospital blood transfusion coalition core competencies for emergency medical services personnel.Trauma surgery & acute care open · 2026Article
- Expanding access to prehospital blood products: a narrative review of clinical evidence, systems barriers, and statewide strategies.Trauma surgery & acute care open · 2026Review
- Potential utility of prehospital blood for trauma patients in a dense, urban setting: simulations of prehospital travel times.Proceedings (Baylor University. Medical Center) · 2026Article
- Nationwide estimates of potential lives saved with prehospital blood transfusions.Transfusion · 2025Article
- Prehospital blood transfusion coalition clinical practice guideline for civilian emergency medical services.Trauma surgery & acute care open · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrehospital blood transfusions result in a significant reduction in mortality risk for injured patients in hemorrhagic shock; however, prehospital blood transfusions have not been widely implemented across the United States. Thus, a paucity of data surrounding the impact of achieving near-complete population-level access to this resource exists. We aimed to determine the number of lives that could potentially have been saved among injured patients in hemorrhagic shock between 2020 and 2023 had prehospital blood products (blood components or whole blood, pBP) been fully implemented.
methodsWe performed a retrospective review of the National Emergency Medical Services Information System (NEMSIS) from 2020 to 2023 for all trauma patients ≥16 years. Patients with prehospital systolic blood pressure <90 mmHg and heart rate >108 beats per minute, or a systolic blood pressure <70 mmHg, and who did not receive pBP products were included in the analysis. Potential lives saved were calculated using mortality and risk ratio estimates (RR) from previously published studies, assuming 100% nationwide access to pBP. A series of models were developed incorporating varying RR, mortality rate assumptions, and nationwide access to pBP to encompass a wide range of scenarios.
resultsA total of 260,472 patients met our inclusion criteria. Using a 22.1% 24-h mortality rate and an RR of 0.629, 21,356 deaths over the four-year study period could have potentially been saved with the nationwide implementation of pBP.
conclusionTransfusion of pBP offers the potential to save thousands of injured patients lives. Efforts toward making policy-level interventions aimed at increasing the adoption and availability of pBP should be sought.
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