Evidence map›Paper›PMID 40059616›Full record

ReviewJournal of neurophysiology2025

Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.

Thiago S Moreira, Ana C Takakura, Barbara Falquetto, Jan-Marino Ramirez, Luiz M Oliveira, Phelipe E Silva, Emmanuel V Araujo

Abstract readReview
In one paragraph

Review in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thiago S MoreiraDepartment of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0002-9789-8296
Ana C TakakuraDepartment of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0001-6273-0760
Barbara FalquettoDepartment of Pharmacology, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
Jan-Marino RamirezCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, United States.ORCID 0000-0002-5626-3999
Luiz M OliveiraCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington, United States.ORCID 0000-0002-4071-4572
Phelipe E SilvaDepartment of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.
Emmanuel V AraujoDepartment of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0002-1388-2722

Funding

Integrative Consequences of HypoxiaP01HL090554 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2008 to 2017
$21.4M
Mechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI NANDURI, JAYASRI · 2019 to 2023
$12.7M
Unraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3M
Unraveling the dynamic mechanisms underlying opioid respiratory depressionR01HL144801 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2019 to 2026
$5.2M
Neuroglial interactions underlying the generation of the sighR01HL151389 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAMIREZ, JAN M. · 2020 to 2023
$3.2M
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 306418/2023-1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 306580/2023-3Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2020/08620-1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/05299-0Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/09377-6Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/09768-5Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2023-00980-7HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL14454HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL126523HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL144801HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL151389NHLBI NIH HHS P01 HL090554NHLBI NIH HHS P01 HL144454NHLBI NIH HHS R01 HL126523NHLBI NIH HHS R01 HL144801NHLBI NIH HHS R01 HL151389
6 · The paper itself

Abstract

Breathing regulation depends on a highly intricate and precise network within the brainstem, requiring the identification of all neuronal elements in the brainstem respiratory circuits and a comprehensive understanding of their organization into distinct functional compartments. These compartments play a pivotal role by providing essential input to three main targets: cranial motoneurons that regulate airway control, spinal motoneurons that activate the inspiratory and expiratory muscles, and higher brain structures that influence breathing behavior and integrate it with other physiological and behavioral processes. This review offers a comprehensive examination of the phenotypes, connections, and functional roles of the major compartments within the brainstem and forebrain respiratory circuits. In addition, it summarizes the diverse neurotransmitters used by neurons in these regions, highlighting their contributions to the coordination and modulation of respiratory activity.

Indexed as

Brain StemNerve NetProsencephalonRespirationAnimalsHumansMotor NeuronsNeural Pathwaysbrainstembreathingforebrainrespiratory chemoreceptorsrhythmogenesis

Identifiers

PMID40059616
PMCPMC12477829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.