ArticleBrain and behavior2025
Activation of SIRT1 by Hydroxysafflor Yellow A Attenuates Chronic Unpredictable Mild Stress-Induced Microglia Activation and Iron Death in Depressed Rats.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.Biochemistry and biophysics reports · 2026Review
- Targeting Programmed Cell Death in Depression: A Review of Traditional Chinese Medicine Interventions Based on Preclinical Evidence.Neuropsychiatric disease and treatment · 2026Review
- Molecular Insights into Oxidative-Stress-Mediated Cardiomyopathy and Potential Therapeutic Strategies.Biomolecules · 2025Review
- Hydroxysafflor Yellow A Mitigates Sepsis-Induced Pulmonary and Intestinal Injury by Inhibiting TP53 Mediated Ferroptosis.Infection and drug resistance · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundHydroxysafflor yellow A (HSYA), the main active ingredient in safflower, possesses antioxidant and anti-inflammatory activities. We confirmed in our previous study that HSYA exerts antidepressant effects, but further investigation is needed to uncover the exact mechanism. Herein, we aimed to explore the antidepressant effects of HSYA based on microglial activation and ferroptosis studies.
methodsThe chronic unpredictable mild stress (CUMS) procedure was used to establish a depression model in rats. Behavioral tests were conducted on rats after HSYA administration. Iba-1 immunostaining was used to determine the activation of microglia in the hippocampus. We examined the iron ion level using a colorimetric method. Assayed by western blot for protein expression.
resultsRats receiving HSYA showed enhanced spatial learning and memory abilities, as well as improvements in depression-like behaviors. HSYA administration reduced Iba-1 expression in CUMS rats' hippocampus, indicating that HSYA suppressed microglial activation. HSYA inhibited CUMS-induced Fe
conclusionHSYA exerts an antidepressant-like effect by inhibiting microglia activation in the hippocampus and inducing SIRT1/Nrf2/NF-kB signaling.
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