Trial reportRespirology (Carlton, Vic.)2025
Mapping Bullous Emphysema With Lung Ultrasound: A Prospective Multicentre Study.
Trial report in Respirology (Carlton, Vic.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04012359 (Lung Ultrasound Characterization of Bullous Emphysema), which is not on this map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Lung Ultrasound Characterization of Bullous Emphysema
Who cites it
3 citing papers in PubMed.
- Mapping Bullous Emphysema With Lung Ultrasound: A Prospective Multicentre Study.Respirology (Carlton, Vic.) · 2025Trial
- Point-of-care ultrasound training using near-peer training and remote Supervision: A pilot randomized controlled trial.The ultrasound journal · 2026Article
- Evaluation of the relationship between lung ultrasound findings and degree of obstruction in newly diagnosed pediatric asthma patients.BMC pediatrics · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesLung ultrasound holds high diagnostic performance for pleural diseases, notably pneumothorax. Bullous emphysema is a potential differential diagnosis of pneumothorax on ultrasound, but its precise semiology is poorly known. This study aimed to delineate the sonographic presentation of bullous emphysema and assess the diagnostic performance of common ultrasound features in identifying bullae.
methodsFrom June 2019 to June 2021, patients with CT scanner-confirmed bullous emphysema were prospectively included. Investigators performed a standardised 14-region lung ultrasound. Sonographic features of bullous and non-bullous regions were compared. Diagnostic performances for bullae were calculated for each sign, and an additive score was constructed using signs with specificity > 85%. Pearson's correlation was used to examine the relationship between this score, bulla size, and respiratory functional parameters.
resultsThirty-six patients were included, mostly male (n = 33 patients, 91.7%), with an average age of 62 ± 11 years. Bullae mostly affected apical regions (n = 24 patients, 67%). Bullous regions displayed a more frequent absence of lung sliding (34% vs. 11% in non-bullous regions, p < 0.01), barcode sign (15% vs. 3%, p < 0.01), increased A-line visibility (16% vs. 8%, p = 0.048), and absence of Z lines (62% vs. 44%, p = 0.018). A bulla-point sign was visualised in 4% of bullous regions. Absent lung sliding was more frequent in patients with pulmonary distension and in apical regions. Patient bulla score (3 [2-6]) correlated with bulla size (r = 0.53 [0.25;0.73], p < 0.001), FEV
conclusionOur findings challenge previous data about the specificity of ultrasound signs of pneumothorax in patients with bullous emphysema, highlighting the need for cautious interpretation in clinical practice.
trial registrationNCT04012359.
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