ArticleBrain and behavior2025
Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody-Associated Disease.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Clinical Prognostic Factors Associated With Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Multicenter Cohort Study.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundStudies in MS and NMOSD have shown that relapses can frequently occur in the same location as the first attack. Factors associated with this outcome in MOGAD are unclear.
objectiveThe objective of this study was to investigate the likelihood of a relapse occurring at the same site in MOGAD.
methodsThis was a UK national cohort study. MOGAD patients with a minimum of one relapse and one year of follow-up were included. To identify factors associated with relapse location, logistic regression was performed.
resultsAn increased risk of a relapse in the same location was observed when the first attack was optic neuritis-for the second attack (OR 12.9, 95% CI 3.31-50.55, p = .001) and all subsequent attacks (OR 5.39 95% CI 1.61-18.03, p = .006). Conversely, a reduced risk of relapse in the same location was associated with transverse myelitis-for the second attack (OR 0.25, 95% CI 0.07-0.82, p = .022) and all subsequent attacks (OR 0.25 95% CI 0.06-0.96, p = .045).
conclusionIn relapsing MOGAD, patients with optic neuritis are at high risk of a new attack in the same location, while those with transverse myelitis are at low risk.
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