ArticleScientific reports2025
Intermuscular adipose tissue affected muscle density more than intramuscular adipose tissue content with opportunistic screening at abdominal CT.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Association between deltoid muscle attenuation and sedation requirement in anterior shoulder dislocation.BMC musculoskeletal disorders · 2026Article
- Intramuscular fat content and the risk of peritonitis in peritoneal dialysis patients.Clinical kidney journal · 2026Article
- Visceral fat area and blood lipids in colorectal cancer: predictors of surgical risk and prognosis.Frontiers in oncology · 2026Article
- BMI-stratified cutoff values for spinal sarcopenia in Chinese adults based on CT measures: a multicentre study.Journal of orthopaedic surgery and research · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
This study aimed to determine whether intermuscular adipose tissue (IMAT) or intramuscular adipose tissue content (IMAC) has a greater effect on skeletal muscle density (SMD) and to explore the underlying mechanisms. We recruited 292 inpatients without musculoskeletal system disease, all of whom underwent abdominal CT. Muscle parameters, including skeletal muscle area (SMA), skeletal muscle index (SMI), SMD, IMAC, and IMAT, as well as fat parameters-subcutaneous fat area (SFA) and subcutaneous fat density (SFD) in the abdominal wall-were measured by two musculoskeletal radiologists using ImageJ software at the third lumbar vertebra (L3) level. One-way ANOVA with LSD (chi-square test for group comparisons where p > 0.05) or Dunnett's T3 test (p < 0.05) was employed to compare muscle parameters between genders and across age groups. The relationship between SMD and muscle measurements was analyzed using Spearman's correlation coefficient. Multiple regression analysis identified and compared factors influencing SMD. SMD was highly correlated with IMAT and IMAC (p < 0.05), moderately correlated with gender, age, and SFA (p < 0.05). Multiple linear regression analysis indicated that IMAC, IMAT, and age significantly affected SMD (p < 0.05), with the order of influence being IMAT (β = -0.616), IMAC (β = -0.429), and age (β = -0.098). SFA and gender did not significantly affect SMD (p > 0.05). The findings revealed that age, IMAT, and IMAC influence SMD, with IMAT exerting the most significant impact.
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Registered trials
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