Evidence map›Paper›PMID 40059230›Full record

ArticleParasitology research2025

Eggs of Schistosoma japonicum deposited in the spleen induce apoptosis of splenic T cells in C57BL/6 mice.

Yanjuan Wang, Yuan Hu, Jing Zhang, Danling Zhou, Yanjun Zhang, Jianping Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanjuan WangShanghai Urban Construction Vocational College, Shanghai, 201415, China.
Yuan HuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission of the People's Republic of China; National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); World Health Organization Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.
Jing ZhangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission of the People's Republic of China; National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); World Health Organization Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.
Danling ZhouShanghai Urban Construction Vocational College, Shanghai, 201415, China.
Yanjun ZhangShanghai Urban Construction Vocational College, Shanghai, 201415, China.
Jianping CaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission of the People's Republic of China; National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); World Health Organization Collaborating Centre for Tropical Diseases, Shanghai, 200025, China. caojp@chinacdc.cn.

Funding

National Nature Science Foundation of China Nos. 82272369Three-Year Initiative Plan for Strengthening Public Health System Construction in Shanghai (2023-2025) Key Discipline Project GWVI-11.1-12
6 · The paper itself

Abstract

To explore the relationship between Schistosoma japonicum egg deposition and the resultant structural damage to the spleen, mice were infected percutaneously with cercariae or eggs were surgically injected into their spleens. Terminal transferase dUTP nick-end-labeling (TUNEL) showed that cells around the S. japonicum eggs were apoptotic in vivo. Flow cytometry revealed a sharp reduction in splenic B and T cells at 8 weeks post-infection (p.i.) and a significant increase in Annexin V positive T cells. Immunochemistry showed that the remaining follicles in the spleen at 16 weeks p.i. comprised mainly B lymphocytes. Comparing T lymphocytes in the spleen and liver egg granulomas showed obvious CD3

Indexed as

ApoptosisSchistosoma japonicumSchistosomiasis japonicaSpleenT-LymphocytesAnimalsB-LymphocytesFemaleFlow CytometryIn Situ Nick-End LabelingMiceMice, Inbred C57BLOvumApoptosisEgg granulomasLymphocytesSchistosoma japonicumSpleen

Identifiers

PMID40059230
PMCPMC11891099

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.