ArticleVeterinary research2025
Transcriptomic analysis revealed ferroptosis in ducklings with splenic necrosis induced by NDRV infection.
Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Multilayered Landscape of Ferroptosis: Plasticity, Propagation, and Evolutionary Perspectives.Antioxidants (Basel, Switzerland) · 2026Review
- Novel Duck Orthoreovirus Induces Ferroptosis in HD11 Cells by Hijacking Cellular Iron Metabolism and Promoting Iron Accumulation.Transboundary and emerging diseases · 2026Article
- Whole-genome characterization and evolutionary analysis of a novel duck reovirus isolated fromVeterinary world · 2025Article
- Metatranscriptomic analysis of the gut virome in Muscovy ducks reveals a novel duck reovirus potentially associated with hepatic and splenic hemorrhage.Frontiers in immunology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Infection with novel duck reovirus (NDRV) results in severe splenic necrosis, leading to immunosuppression, secondary infections with other pathogens, and impairment of the immune effect of the vaccine. However, little is known about NDRV-induced spleen injury and its antagonistic mechanism on the host immune response. In this study, we conducted pathological and comparative transcriptomic analyses of NDRV-infected duck spleens. Our findings elucidated the histopathological progression of splenic necrotic foci formation following NDRV infection and identified splenic macrophages as the primary target cells. RNA-Seq analysis revealed differentially expressed genes that were enriched predominantly in immune system processes, signalling molecules and interactions, and pathways related to cell growth and necrosis. Notably, we observed a significant upregulation of ferroptosis during NDRV infection, characterized by the induction of specific metabolism-related genes such as TfR1, Hmox1, and STEAP3, alongside the downregulation of Fpn expression. Our findings collectively indicate the involvement of ferroptosis in spleen injury induced by NDRV infection. Investigating the mechanism of NDRV-induced ferroptosis in spleen macrophages will contribute to a comprehensive understanding of the pathogenesis associated with NDRV.
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