Evidence map›Paper›PMID 40059212›Full record

ArticleNeurological research and practice2025

Association of high-density lipoprotein cholesterol with reduced intracranial haemorrhage and favourable functional outcome after thrombectomy for ischaemic stroke: a propensity-matched analysis.

Annahita Sedghi, Sonja Schreckenbauer, Daniel P O Kaiser, Ani Cuberi, Witold H Polanski, Martin Arndt, Kristian Barlinn, Volker Puetz, Timo Siepmann

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neurological research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Annahita SedghiDresden Neurovascular Center, Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Sonja SchreckenbauerDresden Neurovascular Center, Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Daniel P O KaiserDresden Neurovascular Center, Institute of Neuroradiology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Ani CuberiInstitute of Radiology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Witold H PolanskiDresden Neurovascular Center, Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Martin ArndtDresden Neurovascular Center, Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Kristian BarlinnDresden Neurovascular Center, Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Volker PuetzDresden Neurovascular Center, Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany.
Timo SiepmannDresden Neurovascular Center, Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, 01307, Dresden, Germany. Timo.Siepmann@uniklinikum-dresden.de.ORCID http://orcid.org/0000-0003-2196-5904

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnimal studies suggest that high-density lipoprotein cholesterol (HDL-C) attenuates reperfusion injury. We aimed to assess whether higher serum HDL-C levels modulate the risk of intracranial haemorrhage (ICH) after thrombectomy in human stroke survivors.

methodsWe included consecutive patients from our prospective anterior circulation large vessel occlusion (acLVO) registry who underwent thrombectomy between 01/2017 and 01/2023 at the tertiary stroke centre of the University Hospital Carl Gustav Carus in Dresden, Germany in a propensity score-matched analysis. We assessed the association between serum HDL-C levels and post-interventional ICH as well as 90-day functional outcome quantified by the modified Rankin Scale (mRS). For sensitivity analysis, we used multivariable lasso logistic regression. Analyses were adjusted for demographics, cardiovascular risk profiles, stroke characteristics, and procedural times.

resultsOf 1702 patients screened, 807 (420 women, median age 77 years [66-84, IQR]) were included. Post-interventional ICH reduced the probability of a favourable functional outcome (90-day mRS 0-2) by 14.8% (ß = 0.15; 95% CI [0.06;0.24]; p = 0.001. An HDL-C level above the median (1.15 mmol/L) decreased the probability of ICH by 13.6% (ß = - 0.14; 95CI% [- 0.22; - 0.05]; p = 0.002) and increased the probability of favourable functional outcome by 13.2% (ß = - 0.13; 95CI% [- 0.22; - 0.05]; p = 0.003). In sensitivity analyses, higher HDL-C levels were independently associated with lower odds of ICH (adjusted OR 0.62; 95% CI [0.43;0.88]; p = 0.008) and higher odds of favourable functional outcome (adjusted OR 0.60; 95% CI [0.40; 0.90]; p = 0.015).

conclusionsIn patients undergoing thrombectomy for acLVO, higher HDL-C levels were associated with a reduced probability of post-interventional ICH and a favourable functional outcome. These observations could not be explained by conventional vascular risk profiles.

Indexed as

BleedingEndovascular therapyFunctional outcomeHigh density lipoproteinIntracranial haemorrhageIschaemic strokeReperfusion injuryThrombectomy

Identifiers

PMID40059212
PMCPMC11921977

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.