ArticleBMC oral health2025
Fluoridated silver nanocomposites for caries management: an in-vitro assessment of the cytological and antibacterial profiles.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Effect of silver diamine fluoride and nanosilver on salivary bacterial counts in children with early childhood caries: a randomized controlled clinical trial.BMC oral health · 2025Trial
- Selenium nanoparticles as a biological safe endodontic irrigant improving root canal sealing.BMC oral health · 2026Article
- Antibacterial effects and remineralization potential of silver nanoparticles in a novel nanosilver fluoride formulation.BMC oral health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSilver nanoparticles (AgNPs) have antibacterial properties with potential applications in managing dental caries. Functionalization with fluoride may further enhance AgNPs' antibacterial efficacy. This study evaluated the impact of fluoridated AgNPs coated with various surface moieties on their safety profile and antibacterial effects against cariogenic bacteria as a potential anti-cariogenic treatment.
methodsAgNP synthesis followed citrate and gallic acid reduction methods with polyethylene glycol (PEG) and polyvinylpyrrolidone coating. Functionalizing AgNPs with sodium fluoride (NaF) proceeded. Testing the safety of synthesized compounds was done on human gingival fibroblasts and oral epithelial cells. Meanwhile, minimum inhibitory concentration (MIC) determination against Streptococcus mutans was executed to verify antibacterial activity.
resultsGallic-reduced AgNPs revealed higher yielding capacity than citrate-AgNPs. Cytologically, PEGylation reinforced citrate-AgNPs stability and improved IC50 range up to ∼ 4.2 × 10
conclusionsThis dual action nanoplatform successfully integrates fluoride and silver components, reducing fluoride concentrations to safety range while maximizing silver's antibacterial properties. Engineered NaF@PEGylated nanosilver formulation represents promising anti-cariogenic strategy that optimizes therapeutic efficacy while maintaining biological safety.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.