Evidence map›Paper›PMID 40059138›Full record

ArticleBMC medicine2025

Distinct airway mycobiome signature in patients with pulmonary hypertension and subgroups.

Chenting Zhang, Bihua Zhong, Qian Jiang, Wenju Lu, Hongkai Wu, Yue Xing, Xuefen Wu, Zizhou Zhang, Yulin Zheng, Peiwen Li and 13 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

23 authors.

Chenting Zhang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Bihua Zhong *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Qian Jiang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Wenju Lu *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Hongkai Wu *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Yue XingState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Xuefen WuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Zizhou ZhangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Yulin ZhengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Peiwen LiDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Foshan (Affiliated Foshan Hospital of Southern Medical University), Guangdong, Foshan, China.
Zhenxiang LiDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Ziying LinState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Yuqin ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Cheng HongState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China.
Zhuxiang ZhaoDepartment of Pulmonary and Critical Care Medicine, Infectious Diseases, School of Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangdong, Guangzhou, China.
Tingting ZhangDepartment of Intensive Care Unit, School of Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China.
Weiquan LiangDepartment of Respiratory and Critical Care Medicine, The Second People's Hospital of Foshan (Affiliated Foshan Hospital of Southern Medical University), Guangdong, Foshan, China.
Yi ZhangDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Caojin ZhangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Jason X-J YuanCenter for Inflammation Science and Systems Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA.
Chunli Liu *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China. chunli@gird.cn.
Jian Wang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China. jianwang@gzhmu.edu.cn.
Kai Yang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital, Guangzhou Medical University, 195 West Dong Feng Road, Guangzhou, Guangdong, 510182, China. kyang31@gzhmu.edu.cn.

Funding

National Natural Science Foundation of China 82241012, 82270052, 82120108001, 82170065, 82170069, 82370063National Science and Technology Innovation 2030, Major Project- Research on Cancer, Cardiovascular, Respiratory and Metabolic Diseases 2024ZD0528700
6 · The paper itself

Abstract

backgroundThe association between lung microbiome and pulmonary hypertension (PH) remain unknown. This study aims to define the airway mycobiome signature and its potential correlation with clinical parameters of PH.

methodsOverall, 244 patients with PH and 120 healthy controls (CON) were recruited from three independent centers. The PH group was divided into subgroups not using antibiotics or corticosteroids (non-ANT/CORT), and those using ANT, CORT, or ANT + CORT within 1 month, and clinical classification (Groups 1, 3, and 4), World Health Organization functional class (I-IV), and disease severity based on mean pulmonary artery pressure or pulmonary vascular resistance levels for in-depth comparison.

resultsDistinct airway mycobiome profiles were observed in PH, CON, and PH subgroups. Linear discriminant analysis effect size analysis showed increased Purpureocillium, Issatchenkia, and Cyberlindnera and decreased Peroneutypa, Simplicillium, and Metarhizium in patients with PH (non-ANT/CORT, ANT, CORT, and ANT + CORT) than in CON. Receiver operating characteristic analysis indicated a strong prediction of the two fungal genera sets in distinguishing PH and its subgroups from CON. The two major fungal phyla, Ascomycota and Basidiomycota, correlated differently with major clinical factors. Increased connections among the top fungal phyla or genera were observed in the PH than in the CON group. Dominant enrichment (Purpureocillium, Issatchenkia, and Cyberlindnera) and diminishment (Peroneutypa, Simplicillium, and Metarhizium) of fungal genera consistently and strongly predicted PH without being influenced by different PH subgroups.

conclusionsThis study provides the first description of the unique airway mycobiome signature in PH and among different PH subgroups.

Indexed as

Hypertension, PulmonaryLungMycobiomeAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedAirwayFungusMicrobiomeMycobiomePulmonary hypertension

Identifiers

PMID40059138
PMCPMC11892250

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