Evidence map›Paper›PMID 40058879›Full record

ReviewEuropean heart journal. Cardiovascular pharmacotherapy2025

New pharmacological agents and novel cardiovascular pharmacotherapy strategies in 2024.

Juan Tamargo, Stefan Agewall, Giuseppe Ambrosio, Claudio Borghi, Elisabetta Cerbai, Gheorghe A Dan, Heinz Drexel, Péter Ferdinandy, Erik Lerkevang Grove, Roland Klingenberg and 8 more

Erratum issuedAbstract readReview
In one paragraph

Review in European heart journal. Cardiovascular pharmacotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Emerging therapies and evolving paradigms in cardiovascular pharmacotherapy.European heart journal. Cardiovascular pharmacotherapy · 2026
    Article
  2. Review
  3. Cardiovascular pharmacotherapy in 2025.European heart journal. Cardiovascular pharmacotherapy · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Juan TamargoDepartment of Pharmacology and Toxicology, School of Medicine, Universidad Complutense, Instituto de Investigación Sanitaria Gregorio Marañón, Avenida Ramón y Cajal s/n, 28040 Madrid, Spain.ORCID 0000-0002-7979-7758
Stefan AgewallInstitute of Clinical Science, Oslo University, 0318 Oslo, Norway.
Giuseppe AmbrosioDepartment of Medicine and CERICLET, University of Perugia School of Medicine, 06156 Perugia, Italy.
Claudio BorghiDepartment of Cardiovascular Medicine, University of Bologna-IRCCS AOU S. Orsola, 40138 Bologna, Italy.ORCID 0000-0001-8039-8781
Elisabetta CerbaiDepartment Neurofarba, Section of Pharmacology and Toxicology, University of Florence, 50121 Firenze, Italy.ORCID 0000-0001-7839-1361
Gheorghe A DanCarol Davila. University of Medicine, Bucharest, Sector 2, Romania.
Heinz DrexelAcademy of Romanian Scientist, Vorarlberg Institute for Vascular Investigation & Treatment (VIVIT), 6800 Feldkirch, Austria.
Péter FerdinandyDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, H-1089, Hungary.
Erik Lerkevang GroveDepartment of Cardiology, Aarhus University Hospital, Aarhus 8200, Denmark.
Roland KlingenbergDepartment of Cardiology, Kerckhoff Heart and Thorax Center, 61231 Bad Nauheim, Germany.
Joao MoraisciTechCare-Center for Innovative Care and Health Technology, Polytechnic University of Leiria, 2414-016 Leira, Portugal.
William ParkerCardiovascular Research Unit, University of Sheffield, Sheffield S5 7AU, UK.
Bianca RoccaDepartment of Medicine and Surgery, LUM University, 70010 Casamassima, Bari, Italy.ORCID 0000-0001-8304-6423
Patrick SulzgruberDepartment of Medicine, Division of Cardiology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-5146-0099
Anne Grete SembPreventive Cardio-Rheuma clinic, Division of Research and Innovation, REMEDY centre, Diakonhjemmet Hospital, 0370 Oslo, Norway.
Samuel SossallaMedical Clinic I, Cardiology and Angiology, Justus-Liebig-University, Giessen, Germany.
Juan Carlos KaskiMolecular and Clinical Sciences Research Institute, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK.ORCID 0000-0001-8068-0189
Dobromir DobrevInstitute of Pharmacology, West-German Heart and Vascular Centre, University Duisburg-Essen, 45122 Essen, Germany.ORCID 0000-0002-4612-117X

Funding

The Role of Inflammasome in the Pathogenesis of Atrial FibrillationR01HL136389 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2017 to 2026
$5.6M
Sex-specific arrhythmogenic mechanisms of atrial fibrillationR01HL131517 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2016 to 2026
$5.0M
Resolution of inflammation and atrial fibrillationR01HL165704 · NHLBI · UNIVERSITY OF MINNESOTA · PI SAMUEL C DUDLEY · 2023 to 2026
$2.9M
Cardiac fibroblast inflammasome and atrial myopathyR01HL163277 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA · 2022 to 2025
$2.8M
Role of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1M
FKBP5 AND CARDIAC ARRHYTHMOGENESISR01HL164838 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2024 to 2026
$1.7M
Deutsche Forschungsgemeinschaft 517043330European Union 965286NHLBI NIH HHS R01 HL131517NHLBI NIH HHS R01 HL136389NHLBI NIH HHS R01 HL160992NHLBI NIH HHS R01 HL163277NHLBI NIH HHS R01 HL164838NHLBI NIH HHS R01 HL165704NIH HHS R01HL136389
6 · The paper itself

Abstract

Despite substantial advances in cardiovascular pharmacotherapy and devices in recent years, prevention and treatment of many cardiovascular diseases (CVDs) remain limited, thus reflecting the need for more effective and safer pharmacological strategies. In this review, we summarize the most relevant studies in cardiovascular pharmacotherapy in 2024, including the approval of first-in-class drugs for the treatment of resistant hypertension and pulmonary arterial hypertension, label expansions for bempedoic acid and semaglutide, and the results of major randomized clinical trials (RCTs) that have met the pre-specified primary endpoints, thereby filling some gaps in knowledge and opening new perspectives in the management of CVD, and those RCTs whose results did not confirm the proposed research hypotheses. We also include a section on drug safety, where we describe the newest data on adverse reactions and drug-drug interactions that may complicate treatment and/or reduce drug adherence with the consequent decrease in drug effectiveness. Finally, we present the most important ongoing phase 2 and phase 3 clinical trials assessing the efficacy and safety of cardiovascular drugs for the prevention and treatment of CVD.

Indexed as

Cardiovascular AgentsCardiovascular DiseasesHumansTreatment OutcomeCardiovascular AgentsCardiovascular drugsCardiovascular pharmacological strategiesCardiovascular pharmacotherapyDrug combinationsDrug interactions and safetyNew cardiovascular drugs

Identifiers

PMID40058879
PMCPMC12046579

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.