Evidence map›Paper›PMID 40058867›Full record

ArticleInternal medicine (Tokyo, Japan)2025

TAFRO Syndrome with Massive Bilateral Adrenal Hemorrhage.

Toshihiro Kobayashi, Hitomi Imachi, Kensaku Fukunaga, Takanobu Saheki, Takafumi Yoshimura, Kurumi Komori, Wenyi Jiang, Haotian Zhang, Rathana Ly, Ryou Ishikawa and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Toshihiro KobayashiDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.
Hitomi ImachiDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.
Kensaku FukunagaDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.
Takanobu SahekiDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.
Takafumi YoshimuraDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.
Kurumi KomoriDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.
Wenyi JiangDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.
Haotian ZhangDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.
Rathana LyDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.
Ryou IshikawaDepartment of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Japan.
Reiji HabaDepartment of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Japan.
Hiroaki DobashiDivision of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Japan.
Koji MuraoDepartment of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the case of a 62-year-old man who presented with bilateral adrenal enlargement and systemic lymphadenopathy. Imaging and clinical findings led to the diagnosis of bilateral adrenal hemorrhage. Bone marrow aspiration and lymph node biopsy confirmed TAFRO syndrome, which met the established diagnostic criteria. Although adrenal hemorrhage in TAFRO syndrome is exceedingly rare, this case is unique, as it represents the first reported instance of massive bilateral adrenal hemorrhage with confirmed progression. This case underscores the need for awareness regarding this potential complication of TAFRO syndrome.

Indexed as

Adrenal Gland DiseasesCastleman DiseaseHemorrhageHumansMaleMiddle Agedbilateral adrenal hemorrhageTAFRO syndrome

Identifiers

PMID40058867
PMCPMC12463431

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.