Evidence map›Paper›PMID 40058862›Full record

ReviewInternal medicine (Tokyo, Japan)2025

Diffuse Alveolar Hemorrhage Associated with Herbal Medicine: A Case Series and Literature Review.

Kazuo Tsuchiya, Ryota Miyamoto, Tomo Tsunoda, Taisuke Ito, Takuro Akashi, Yoshiyuki Oyama, Masaki Ikeda

Abstract readCase ReportsReview
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kazuo TsuchiyaDepartment of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Japan.
Ryota MiyamotoDepartment of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Japan.
Tomo TsunodaDepartment of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Japan.
Taisuke ItoDepartment of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Japan.
Takuro AkashiDepartment of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Japan.
Yoshiyuki OyamaDepartment of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Japan.
Masaki IkedaDepartment of Respiratory Medicine, Shizuoka Saiseikai General Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although there have been several reports of drug-induced pneumonitis caused by herbal medicines in recent years, herbal medicine-induced diffuse alveolar hemorrhage (DAH) is rare. We herein report two cases of DAH associated with herbal medicines. Patient 1 developed dyspnea and hemoptysis after receiving jidabokuippo. Patient 2 developed a fever and dyspnea after taking otsuji-to. Both patients exhibited severe respiratory failure, and bronchoalveolar lavage revealed bloody fluid that confirmed the diagnosis of DAH. In both patients, discontinuation of herbal medicines and corticosteroid therapy resulted in significant improvement. These cases highlight the potential risks of DAH associated with herbal medicines.

Indexed as

Drugs, Chinese HerbalHemorrhageLung DiseasesPulmonary AlveoliHumansDrugs, Chinese Herbaldiffuse alveolar hemorrhagedrug-induced lung injuryglycyrrhizaherbal medicine

Identifiers

PMID40058862
PMCPMC12463424

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.