ArticleFukushima journal of medical science2025
Impact of COVID-19 pandemic on unresectable pancreatic cancer: a regional cohort study in Japan.
Article in Fukushima journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
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Abstract
backgroundThe COVID-19 pandemic has had a significant impact on healthcare, including cancer management. This study aimed to investigate the prognostic impact of the COVID-19 pandemic, throughout its duration, on patient care for pancreatic ductal adenocarcinoma (PDAC).
methodsWe collected clinical data of patients with unresectable PDAC who underwent palliative chemotherapy at five medical facilities in Fukushima, Japan. The patients were divided into two groups: group A (nonpandemic cohort) and group B (pandemic cohort). Survival analysis was performed for progression-free survival (PFS) and overall survival (OS) via the Kaplan‒Meier method with the log-rank test.
resultsIn total, 249 patients were selected for the analysis. Patients in Group B had significantly greater serum CA19-9 levels and proportions of patients selected for combination therapy; however, we did not find significant differences between the two groups in PFS (Group A vs. Group B: 5.6 months vs. 4.4 months, HR = 0.82 (95% CI, 0.6-1.1), p = 0.17) or OS (14.8 months vs. 12.3 months, HR = 0.81 (95% CI, 0.7-1.3), p = 0.81) in the survival analysis.
conclusionsWe did not observe a negative impact on the prognosis of patients with unresectable PDAC throughout the COVID-19 pandemic.
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