ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2025
Latent Profiles of Impulsivity and Emotion Regulation in Children With Externalizing Disorders Are Associated With Alterations in Striatocortical Connectivity.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Temperament Subtypes and Psychopathology Among Clinically Referred Juvenile Offenders.Psychiatry investigation · 2026Article
- Risk calculation circuit abnormalities plus psychosocial risk variables predict problematic substance use in youth with externalizing disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Familial risk factors required to predict earlier adolescent substance use in youth with externalizing disorders.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Violence and threat exposure is associated with frontostriatal alterations during risky decision-making in children with co-morbid ADHD and disruptive behavior disorders.Frontiers in psychiatry · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundChildren with externalizing disorders often have difficulties with impulsivity (IMP) and emotion regulation (ER). These constructs have been associated with dysfunction in the recruitment of reward-processing circuits and striatal connectivity with cortical networks. However, it is unclear to what extent co-presentations of IMP and ER are associated with differences in striatocortical connectivity.
methodsIn study 1, a latent profile analysis (LPA) was conducted in a sample of 198 youths with externalizing disorders (oppositional defiant disorder and/or conduct disorder) to investigate co-presentation of IMP and ER symptoms. Participants completed the UPPS Impulsivity Scale (UPPS) and the Emotion Regulation Checklist (ERC). LPA was applied to the subscales of the UPPS and ERC. In study 2, we examined 169 participants who completed a resting-state functional magnetic resonance imaging scan to examine differences in striatocortical connectivity between profiles.
resultsThe LPA identified 3 profiles: moderate IMP/moderate ER, high IMP/low ER, and high IMP/moderate ER. The 2 high IMP profiles were associated with greater connectivity between the posterior caudate nucleus and parietal cortex. The high IMP/low ER profile was associated with increased connectivity between the anterior caudate and anterior insula.
conclusionsThe current data indicate that the profiles associated with high IMP are associated with greater caudate-parietal cortex connectivity, while the profile associated with high IMP and impaired ER showed increased anterior caudate-anterior insular cortex connectivity. The current work contributes to the literature by examining the relationship between heterogeneity of externalizing symptoms and functional connectivity.
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