ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2025
Development and Preliminary Validation of Standardized Regression-Based Change Scores as Measures of Transitional Cognitive Decline.
Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Multimodal biomarker characterization of amnestic objective subtle cognitive decline in aging and preclinical Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2026Observational
- Reliability of remote self-administered web-based digital cognitive measures and comparison to in-person neuropsychological tests: Stricker Learning Span, Symbols Test and the Mayo Test Drive Screening Battery Composite.medRxiv : the preprint server for health sciences · 2025Article
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5 authors.
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Abstract
objectiveAn increasing focus in Alzheimer's disease and aging research is to identify transitional cognitive decline. One means of indexing change over time in serial cognitive evaluations is to calculate standardized regression-based (SRB) change indices. This paper includes development and preliminary validation of SRB indices for the Uniform Data Set 3.0 Neuropsychological Battery, as well as base rate data to aid in their interpretation.
methodThe sample included 1341 cognitively intact older adults with serial assessments over 0.5-2 years in the National Alzheimer's Coordinating Center Database. SRB change scores were calculated in half of the sample, then validated in the other half of the sample. Base rates of SRB decline were evaluated at z-score cut-points, corresponding to two-tailed p-values of .20 (z = -1.282), 0.10 (z = -1.645) and .05 (z = -1.96). We examined convergent associations of SRB indices for each cognitive measure with each other, as well as concurrent associations of SRB indices with Clinical Dementia Rating sum of box scores (CDR-SB).
resultsSRB equations were able to significantly predict the selected cognitive variables. The base rate of at least one significant SRB decline across the entire battery ranged from 28.91% to 64.90%. SRB indices for cognitive measures demonstrated theoretically expected significant positive associations with each other. Additionally, CDR-SB impairment was associated with decline on three different SRB indices.
conclusionsThis paper provides preliminary validation of SRB indices in a large sample, and we present a user-friendly tool for calculating SRB values.
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