Evidence map›Paper›PMID 40057949›Full record

ArticleCell reports2025

BATF2 is a regulator of interferon-γ signaling in astrocytes during neuroinflammation.

Rachel A Tinkey, Brandon C Smith, Maria L Habean, Jessica L Williams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Astrocytes in Multiple Sclerosis: Getting to the Core.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Rachel A TinkeyDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; School of Biomedical Sciences, Kent State University, Kent, OH 44240, USA.
Brandon C SmithDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Maria L HabeanDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Jessica L WilliamsDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: williaj39@ccf.org.

Funding

Pathogenesis of Neurological Disability in Primary Diseases of MyelinR35NS097303 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI TRAPP, BRUCE D · 2017 to 2024
$6.9M
The role of the astrocyte immunoproteasome during chronic CNS autoimmunityR01NS119178 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI WILLIAMS, JESSICA L · 2021 to 2025
$2.0M
NINDS NIH HHS R01 NS119178NINDS NIH HHS R35 NS097303
6 · The paper itself

Abstract

Astrocytic interferon (IFN)γ signaling is associated with reduced neuroinflammation; however, downstream effectors responsible for regulating this protection are unknown. Here, we identify an IFN-specific transcription factor, basic leucine zipper ATF-like transcription factor (BATF)2, that plays a key role in modulating the consequences of IFNγ signaling in astrocytes. Chromatin immunoprecipitation sequencing revealed that BATF2 binds and prevents the overexpression of IFN regulatory factor (IRF)1 and IRF1 targets such as caspase-1. We also show that Batf2

Indexed as

AstrocytesBasic-Leucine Zipper Transcription FactorsInterferon-gammaNeuroinflammatory DiseasesRepressor ProteinsSignal TransductionAnimalsEncephalomyelitis, Autoimmune, ExperimentalHumansInterferon Regulatory Factor-1MiceMice, Inbred C57BLMice, KnockoutBasic-Leucine Zipper Transcription FactorsBATF2 protein, mouseInterferon-gammaInterferon Regulatory Factor-1Repressor ProteinsastrocyteautoimmunityBATF2CP: ImmunologyCP: NeuroscienceIFNγinterferonmultiple sclerosisneuroinflammation

Identifiers

PMID40057949
PMCPMC12010240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.