Evidence map›Paper›PMID 40057777›Full record

ArticleBMC complementary medicine and therapies2025

Flavonoids of Andrographis paniculata regulate hepatitis B virus replication and hepatocellular carcinoma progression: evidence from computational and experimental studies.

Vishal S Patil, Darasaguppe R Harish, Rajitha Charla, Vishwambhar Vishnu Bhandare, Swarup S Gujarathi, Faizan A Beerwala, Priyanka P Patil, Sunil S Jalalpure, Harsha V Hegde, Subarna Roy

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Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vishal S PatilICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India.
Darasaguppe R HarishICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India. harish.dr@icmr.gov.in.
Rajitha CharlaICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India.
Vishwambhar Vishnu BhandareICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India.
Swarup S GujarathiICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India.
Faizan A BeerwalaICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India.
Priyanka P PatilICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India.
Sunil S JalalpureICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India. jalalpuresunil@rediffmail.com.
Harsha V HegdeICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India.
Subarna RoyICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe HBx protein of hepatitis B virus (HBV) plays a crucial role in HBV pathogenesis, yet current treatments like HIV reverse transcriptase (RT) inhibitors, which target HBV RT due to similar active sites, have severe side effects, risk of drug resistance, and high costs. The present study investigates the anti-hepatitis B virus (HBV) properties of Andrographis paniculata (AP) and Thespesia populnea (TP) on HBV expressing HepG2.2.15 cells and by computational analysis.

methodsIn vitro cytotoxicity, reverse transcriptase inhibitory, DNA and pgRNA quantification by qRT-PCR, time course analysis of HBsAg and HBeAg, and HBX-HBXIP interaction inhibition studies were conducted. The interaction of HBX with HBXIP, and phytocompounds' interaction with HBx was analyzed through molecular docking and dynamics studies.

resultsAP exhibits lower cytotoxicity (CC

conclusionsAP exhibits potent anti-HBV activities, making it a promising candidate for further therapeutic development.

Indexed as

AndrographisAntiviral AgentsCarcinoma, HepatocellularFlavonoidsHepatitis B virusLiver NeoplasmsPlant ExtractsVirus ReplicationHep G2 CellsHumansMolecular Docking SimulationAntiviral AgentsFlavonoidsPlant ExtractsAndrographis paniculataHBxHepatitis B virusHepG2.2.15In silico

Identifiers

PMID40057777
PMCPMC11889761

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.